New study from Seoul University: Illustrates the biological mechanism of lung cancer caused by smoking and long-term stress.

A new study from Seoul University in South Korea sheds light on the biological mechanisms of lung cancer caused by smoking and long-term stress at the cellular level.
studies have confirmed that not only can cigarette fumes cause lung cancer, but long-term stress can also cause cancerous epithelial cells in the lung tissue of laboratory mice.
In animal trials, some drugs for high blood pressure can significantly reduce the incidence of lung cancer.
the study found that the carcinogenic components in cigarette incendiary substances and stress caused by high expression of hormone-like substances, can improve the activity of the pulmonary epithelial cell membrane voltage-dependent calcium channel, so that the calcium ions entering the cell exceed normal levels.
these calcium ions enhance the activity of insulin receptors, causing epithelial cell carcinoma.
and after the calcium ion channel blocker treatment of epithelial cell blockers in human lung tissue and laboratory laboratory lung tissue, the activity of insulin-like receptors was curbed, and the resulting epithelial cell cancer was greatly reduced.
The researchers explained that the calcium ion channel blocker (CCB) is a class of drugs that block calcium ions through the cell membrane calcium ion channel into the cell' internal, widely used in hypertension and the treatment of cardiovascular-related diseases.
on the basis of this results, through new clinical trials, it is hoped that the development of a drug can prevent lung cancer.
experiments showed that the volume of the tissue mass in the lung cells of mice was positively correlated with strong levels of mental stress.
mice exposed to cigarette fumes and in external mental stress showed significantly lower cancer rate of lung tissue after administration by calcium ion channel blockers.
lung cancer related information: lung cancer is China and even the world's high incidence and mortality rate of malignant tumors, China's annual incidence and mortality rate of about 400,000 people diagnosed with lung cancer, it is expected that by 2025, the number of people dying from lung cancer alone will be close to 1 million.
focus on the new development of lung cancer treatment With the development of medicine, the treatment strategy of lung cancer is becoming more and more abundant, and the treatment of lung cancer and even the whole field of cancer has changed greatly.
According to clinically effective data, through active drug treatment, chemotherapy, radiotherapy, targeted treatment and other means, can significantly prolong the survival of patients, reduce the risk of death, but the common people (603883, stock bar) still talk about cancer color change.
facing this situation, Wu Zhiyong, deputy director of oncology medicine at the Chinese People's Liberation Army General Hospital (301 Hospital), stressed that patients should accept the following three concepts.
first, mentality.
patients should accept lung cancer psychologically as a chronic disease state, accept the state of tumor survival, clinically shows that through effective treatment, lung cancer patients can be effectively controlled.
patients should believe in effective clinical data, change their mentality and reduce the psychological burden.
second, therapy.
patients follow the advice of the attending physician, actively communicate with the doctor, develop a comprehensive treatment plan.
do not blindly share according to experience, sick friends to explore, increase or decrease drugs, so as not to cause irreversible consequences.
at the same time, it is recommended that the family reasonable let the patient understand the condition, so as to receive good treatment.
third, do not blindly resist radiotherapy, chemotherapy.
clinic, often patients and family members often ask doctors "can not do chemotherapy", there is a natural resistance to chemotherapy and fear.
in fact, chemotherapy plays an important role in the whole treatment of lung cancer, for some patients with subtypes of lung cancer, but also to cure the disease, so that patients benefit, to obtain an important weapon for survival.
adverse reactions in the course of radiotherapy and chemotherapy, such as common nausea, vomiting, white blood cell decline, etc., have been effectively alleviated through the active treatment of doctors, complementary treatment and the development of drugs.
under the premise of actively cooperating with doctors, some lung cancer patients in the oncology department of 301 Hospital did not have adverse reactions, which not only ensured the quality of life of patients, but also had good treatment results.
the inclusion of lung cancer targeted drugs in the national health insurance to help patients overcome economic barriers In recent years, the clinical treatment of lung cancer has made several breakthroughs, among which the application of molecular targeted treatment drugs is an important leap, is expected to turn lung cancer into a controllable and curable chronic disease.
but by 2017, targeted drugs will be expensive.
the 2017 national negotiations, a number of innovative malignant tumor drugs into the scope of medical insurance reimbursement, such as one of the commonly used drugs, Trokai (ellotinib hydrochloric acid), included in the health insurance price significantly reduced, since the implementation of the policy, patients significantly reduced the financial burden, directly benefit. Wu Zhiyong, deputy director of oncology medicine at
301 Hospital, said: "In the past, because targeted drugs are not covered by medical insurance reimbursement, due to financial burden considerations, doctors and patients often have concerns about the choice of targeted drugs, limiting the clinical application of targeted treatment in China, now more targeted drugs into the medical insurance, greatly reducing the financial burden of patients, helping more patients, giving them comprehensive support, improve the confidence of the whole society in cancer treatment!" "About lung cancer: Lung cancer is one of the most common and mortality cases and one of the most life-threatening malignancys.
in many countries in the past 50 years, the incidence and mortality of lung cancer have increased significantly, with male lung cancer incidence and mortality accounting for the first of all malignant tumors, women in the second and the second. the cause of lung cancer
is still not completely clear, a large number of data show that long-term large-scale smoking and lung cancer has a very close relationship.
existing studies have shown that long-term large numbers of smokers are 10 to 20 times more likely to develop lung cancer than nonsmokers, and the younger they start smoking, the higher their chances of developing lung cancer.
, smoking not only directly affects my health, but also has adverse effects on the health of the surrounding population, resulting in a significant increase in the prevalence of lung cancer among passive smokers.
the incidence of lung cancer in urban residents is higher than in rural areas, which may be related to urban air pollution and the exposure of carcinogens in soot.
should therefore promote non-smoking and strengthen urban sanitation. the causes of lung cancer in
are six points: 1. Smoking is currently considered to be the most important high risk factor for lung cancer, tobacco has more than 3000 chemicals, of which multi-chain aromatic hydrocarbons (e.g. benzodiazepines) and nitrosamines have strong carcinogenic activity.
multi-chain aromatic hydrocarbons and nitrosamines can cause the DNA damage of bronchial epithelial cells through a variety of mechanisms, causing the activation of cancer genes (such as Ras genes) and the inactivation of cancer-suppressing genes (such as p53, FHIT genes, etc.), which inturn that cause cell transformation and eventual cancer.
2. Occupational and environmental exposure to lung cancer is the most important type of occupational cancer.
estimated that about 10% of lung cancer patients have a history of environmental and occupational exposure.
has now been shown to increase the incidence of lung cancer in nine occupational environmental carcinogens: by-products of aluminum products, arsenic, asbestos, bis-chloromethylether, chromium compounds, coke ovens, mustard gas, impurities containing nickel, and vinyl chloride.
long-term exposure to substances such as radon, cadmium, silicon and formarin will also increase the incidence of lung cancer, which can cause lung cancer in air pollution, especially industrial exhaust gases.
3. Ionizing radiation lungs is an organ that is more sensitive to radiation.
the first evidence of lung cancer caused by ionizing radiation comes from data from the Schneeberg-joakimov mine, where radon and its sub-bodies are concentrated in the air, which is mostly small cell carcinoma of the bronchial tube.
the United States has reported that 70% to 80% of miners mining radioactive ore died of radioactive-induced occupational lung cancer, mainly scale cancer, from the beginning of exposure to the onset of 10 to 45 years, the average time of 25 years, the average age of the onset of 38 years. The incidence of
and its sub-body accumulation exceeds 120 working days (WLM), while the incidence increases significantly by 20 to 30 times over 1800WLM.
exposing mice to the gas and dust of these mines can induce lung tumors.
a significant increase in lung cancer among survivors of the atomic bombing in Japan.
Beebe, during a lifetime follow-up visit to survivors of the Hiroshima atomic bombing, found that survivors with a heart of less than 1400m had a significant increase in lung cancer deaths compared to those who were 1400 to 1,900m and 2000m away from the blast.
4. In patients with chronic lung infections such as tuberculosis and bronchodilatorism, the bronchial epithelial may become scaly epithelial cancer in the course of chronic infection, but it is rare.
5. Genetic and other factors family aggregation, genetic susceptibility and decreased immune function, metabolism, endocrine dysfunction, etc. may also play an important role in the occurrence of lung cancer.
many studies have shown that genetic factors may play an important role in people and individuals who are susceptible to environmental carcinogens.
6. The high incidence of lung cancer in developed countries with atmospheric pollution is mainly due to the pollution of the atmosphere by harmful substances such as benzodiazepine carcinogenic hydrocarbons produced by combustion and asphalt road dust in developed areas of industry and transportation, such as oil, coal and internal combustion engines.
air pollution and smoking may promote and synergy in lung cancer incidence.
Source: Decoding Medicine, Legal Evening News.