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Some people become very ill after contracting SARS-CoV-2, while others have only mild symptoms or no symptoms at all
.
In addition to chronic disease risk factors such as advanced age and diabetes , our genetics also contribute to this phenomenon
Some people become very ill after contracting SARS-CoV-2, while others have only mild symptoms or no symptoms at all
A study led by Germany's Max Planck Institute for Evolutionary Anthropology (MPI-EVA) has shown that the same genetic variant that increases the risk of severe illness from COVID-19 protects against another serious disease -- which infects a person with HIV.
The risk of the virus was reduced by 27%
We are born with genetic variants that can increase or decrease our risk of severe COVID-19
.
A major genetic risk variant of severe COVID-19, the one we inherit from Neanderthals, is surprisingly common
We are born with genetic variants that can increase or decrease our risk of severe COVID-19
In the fall of 2020, Hugo Zeberg of Karolinska Institutet and MPI-EVA and Svante Pääbo of MPI-EVA have discovered that we inherit a major genetic risk variant from Neanderthals that increases the risk of severe COVID-19
.
In the spring of 2021, they studied this variant in ancient human DNA and observed that its frequency has increased significantly since the last ice age
In the fall of 2020, Hugo Zeberg of Karolinska Institutet and MPI-EVA and Svante Pääbo of MPI-EVA have discovered that we inherit a major genetic risk variant from Neanderthals that increases the risk of severe COVID-19
This genetic risk variant is located on chromosome 3 in a region of many genes
.
In its vicinity are several genes encoding receptors in the immune system
This genetic risk variant is located on chromosome 3 in a region of many genes
However, because HIV only emerged in the 20th century, reducing the risk of developing the infectious disease cannot explain why this genetic risk variant of COVID-19 was so prevalent in humans as early as 10,000 years ago
.
Zeberg concluded, "Today we know that this risk variant of COVID-19 provides protection against HIV infection
However, because HIV only emerged in the 20th century, reducing the risk of developing the infectious disease cannot explain why this genetic risk variant of COVID-19 was so prevalent in humans as early as 10,000 years ago
Reference:
Hugo Zeberg.
The major genetic risk factor for severe COVID-19 is associated with protection against HIV.
PNAS, 2022, doi:10.
1073/pnas.
2116435119.
Hugo Zeberg.
The major genetic risk factor for severe COVID-19 is associated with protection against HIV.
PNAS, 2022, doi:10.
1073/pnas.
2116435119.
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