New study: Non-neuron cells in the brain can be converted into functional neurons
-
Last Update: 2020-11-28
-
Source: Internet
-
Author: User
Search more information of high quality chemicals, good prices and reliable suppliers, visit
www.echemi.com
in separate human cells and mice, researchers used a one-step approach to convert non-neuron cells in the brain into functional neurons, according to a new neuroscience paper published in the international academic journal Nature. The technique has been shown to reverse symptoms in mouse models of Parkinson's disease or suggest a new way to explore treatments for neurodegenerative diseases.
the study notes that one of the main goals of regenerative medicine is to replace neurons lost in neurodegenerative diseases and to promote the integration of new neurons into functional neural loops. Parkinson's disease, for example, is characterized by the loss of dopamine-energy neurons in the brain region responsible for reward and exercise.
study's co-author, Professor Fu Fudong of the University of California, San Diego, and colleagues have shown that astrological glial cells can be converted into functional dopamine neurons. Astrological glial cells are non-neuronal cells in the brain that produce an RNA binding protein called PTBP1, which prevents astrological glial cells from becoming neurons.
PTBP1 could turn astrological glial cells into functional neurons and reconstruct lost neuronal loops, the authors said. It also restores dopamine levels in parkinson's mice and treats their movement disorders. Importantly, the short-term suppression of PTBP1 with antisant oligonucleotides has also been effective, and the treatment has shown great prospects in the treatment of neurodegenerative diseases.
industry believes the latest study offers a new regenerative therapy for neurodegenerative diseases. However, the authors caution that research is still needed before the therapy can actually be used in humans. With further refinement, the treatment is expected to treat Parkinson's disease and other neurodegenerative diseases. (Complete)
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.