New target for treating pancreatic cancer found! Cersei, the king of cancer, trembles!
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Last Update: 2020-06-01
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Source: Internet
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Author: User
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File: For this experiment, FASEB J researchers first produced protein modifications from pancreatic cancer cell lines for drug-resistant and non-drug-resistant cellsBy comparing these maps, they found changes in the modification of specific proteins associated with drug-resistant cellsAmong the drug-resistant cells is PML, known for its involvement in an invasive leukemiaUsing cultured cells, the researchers found that a change in PML modification, known as ubiquitin-like, was also involved in pancreatic cancer cells' resistance to chemotherapy treatmentUsing heterogeneous transplant models from patient sources, the researchers found that patients with high PML expression and higher levels of PML ubiquity had higher survival ratesInstead, the study showed that patients with low PML expression and low PML ubiquity had worse survival rates because their tumors showed resistance to chemotherapy treatment"These findings can improve the prognosis of pancreatic cancer patients in a relatively short period of time," said DrPhilippe Soubeyran, a researcher at the Marseille Cancer Research Centre (CRCM) at the National Institute of Health and Medical Research in France"In the long run, we may be able to improve the treatment of pancreatic cancer by restoring the drug's efficacy against drug-resistant tumorsDr Thoru Pederson, editor-in-chief of theFASEB journal, said: "It is an interesting finding that the post-translation modification of this protein is so decisiveThis not only resets the therapeutic dimension, but may also indicate similar cancer protein events in other malignant tumorsReference: Philippe Soubeyran et alPML hyposumoylation is responsible for the resistance of the dalsin cancerThe FASEB JournalDOI: https://doi.org/10.1096/fj.201901091R
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