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Scientists at Münster University have recently developed a new type of nanocontainer composed entirely of biological components
Scientists hope to use this micro-nanocontainer with a diameter of about 150 nanometers to load cells with lipids that are labeled with biological significance.
Bio-inspired materials organize themselves to form a cargo container
In order to synthesize new cargo carriers, scientists used sugar compounds (modified cyclodextrins), which are similar in structure and behavior to certain lipids naturally present in every cell
Nanocontainers that use natural pathways to enter cells
In the next step, the scientists studied whether and how the newly developed nanocontainers are occupied by cells
The container shell is degraded by enzymes in the endosome
The conditions inside the endosomes are different from the cellular environment, which is what scientists have considered when designing the nanocontainer
Journal Reference :
Sergej Kudruk, Sharafudheen Pottanam Chali, Anna Livia Linard Matos, Cole Bourque, Clara Dunker, Christos Gatsogiannis, Bart Jan Ravoo, Volker Gerke.