New technology of NK cell engineering based on bioorthogonal sugar metabolism and nanotechnology

Recently, a nanomedicine research group led by Cai Lintao, a researcher at Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, has made new breakthroughs in NK cell engineering based on bioorthogonal sugar metabolism and nanotechnolog.

Screenshot of the paper online 

Original link: https://onlinelibra.

Natural killer ( NK )-based immunotherapy has outstanding potential in cancer treatme.

In this paper , bioorthogonal groups ( -N ₃ /-BCN ) were implanted on the surface of NK cells and tumor cells through non-destructive bio-orthogonal glycometabolism engineerin.

At the same time, compared with traditional systemic administration, NK cell-conjugated ILNPs nanoparticles can release IL-21 adjuvant in situ in tumors, resulting in effective and sustained " pseudo-autocrine " stimulation of NK cells at low dose.

New technology of NK cell engineering based on bioorthogonal sugar metabolism and nanotechnology

Introduction of PI and research group:

Cai Lintao , researcher, doctoral supervisor, director of the Institute of Medicine, Shenzhen Institute of Advanced Medicine, Chinese Academy of Sciences, director of the Nano Cent.

Li Wenjun , associate researcher, doctoral supervisor , Shenzhen high-level talent category.

Gong Ping , researcher, doctoral supervisor, has presided over a number of scientific research projects such as the National Natural Science Foundation of China, the Youth Fund, the Natural Science Foundation of Guangdong Province, and the Shenzhen Science and Technology Research Program; participated in973 , 863 , National Natural Science Foundation and other projects for many times of resear.