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As humans, we have a huge and complex folded neocortex that explains many of our intellectual abilities and distinguishes us from all other species
This paper was published in the "Science Advances" magazine on the 15th
How does the human brain develop?
The neocortex is composed of six neuron layers and many functional areas
How brain growth is controlled is unclear
Although researchers have been very interested in elucidating this development in recent years, so far they have only been able to identify a few factors that play a role in it
To test whether the expansion of the cortex during evolution is related to changes in the epigenetic landscape, the authors first investigated whether the epigenetic markers between TBR2-positive (+)BPs in mouse and human cortex are different
The team used a new technique based on mass spectrometry to detect differences in the epigenetic landscape of the developing mouse and human brains
These results indicate that manipulating H3 acetylation in basal progenitor cells can help generate more neurons, which can be used to treat neurodegenerative diseases
Science Advances
DOI
10.