New technology quickly achieves high-definition imaging of deeper tissues in the brain

According to a paper published in the journal "Science Advances" on the 7th local time, a research team from the Massachusetts Institute of Technology and Harvard University has developed an improved version of the two-photon imaging microscope, which allows scientists to obtain faster access to blood vessels and blood vessels in the brain.

Researchers often use two-photon microscopes to make high-resolution 3D images of tissues such as the brain

In order to improve the imaging technology, the research team's goal is to achieve rapid imaging of a large tissue sample at one time while maintaining the pixels that scan the tissue point by point for high-definition imaging

This time, the researchers used a wide-view microscope to change the amplitude of the light and irradiate one side of the light on the tissue so that each pixel can be turned on or off at different times

Using this technology, the researchers demonstrated that they can achieve about 200-micron-scale imaging in muscle and kidney tissue slices, and about 300-micron imaging in mouse brains

"The imaging of blood vessels in the rat brain may be particularly useful for understanding more about how neurodegenerative diseases such as Alzheimer's disease affect blood flow

Yildirim also said that all studies on blood flow or vascular structure are based on two-photon or three-photon point scanning systems.

The technology can also measure neuronal activity by adding voltage-sensitive fluorescent dyes or fluorescent calcium probes, and can also be used to analyze tumors and other types of tissues, such as helping to determine the edge of a tumor

Editor-in-chief

We still cannot say "understanding" about this organ of the brain