New treatment for cerebral infarction extends treatment time window to improve treatment rate

Scientists at the University of California, Los Angeles (UCLA) recently brought together a new treatment that offers more opportunities for patients who miss the window of time: neurostimulation therapy can help patients recover within 24 hours of a brain infarctionThis important study was published in Lancetpicture source: Lancet's websitedifferent from the current treatment of vascular re-transmission through thrombosis, hydrant, this new treatment on nerve cell clusters after the nose to apply electrical stimulationMechanism studies have shown that stimulating clusters of nerve cells can increase blood flow in the brain by expanding undamaged arteries and bypassing blocked areas, reducing the threat to the brain from ischemia, while not affecting the blood-brain barrier, preventing cerebral edematreatment requires a 23mm long, 2mm diameter neurostimulator electrode temporarily implanted from the top of the mouth through a syringe under local anaestheticDuring the trial, the electrodestimulated nerve cell clusters for 4 hours a day for 5 consecutive dayselectrodes (A) and syringes (B) that require temporary implantation (Photo: Resources 1)ImpACT-24B is a randomized double-blind trial conducted in 73 centres in 18 countriesThe study recruited patients with precirculation acute ischemic stroke who did not receive refill therapyPatients were randomly grouped to receive a cerustosis nerve or false stimulation within 8-24 hours of the onset of a cerebral infarctionThe main therapeutic endpoint was the proportion of patients whose disability improved more than expected at 3 monthsBetween June 10, 2011 and March 7, 2018, a total of 1,000 patients received intervention, 481 received a cernal stimulation of the butterfly palate, and 519 received false stimulationAfter 3 months of stimulation, the improvement in disability was better than expected in the treatment group and 45% in the intervention group, respectivelyOf the 520 patients with severe symptoms and confirmed cerebral cortical damage, 50 percent of the patients in the stimulation group recovered more than expected and 40 percent of the control groupAlthough these data were not statistically significant, when combined with similar data from earlier trials, the results showed that neurostimulation therapy was effective and improved the degree of disability in patients with cerebral cortical impairment within 8-24 hours of acute cortical ischemic strokeIn terms of safety, there was no difference in severe adverse events and mortality rates between the two groups it's worth noting that the new therapy doesn't require a high dose of stimulation The stimulation intensity and disability improvement effect of the palate nerve section showed a reverse U-shaped trend, which was very small in all patients, but was more pronounced in patients with cerebral cortical injury, and at low-to-medium stimulation intensity, the proportion of patients with above-expected symptoms improved by 70% in all patients (left) and patients with cerebral cortical damage (right), the effect softening of different stimuli (Photo: Source: 1) usually, after the onset of the disease, the thrombosis drug can effectively relieve arterial obstruction, restore blood flow and avoid damage to the brain However, if not treated in a timely manner, the effectiveness of re-use of drugs after 3 hours of the onset of the disease will decline, and many patients are no longer even suitable for thrombosis treatment While mechanical hydrants can extend the patient's treatment window to 24 hours after the brain infarction, most medical centers may lack the expertise in equipment and operations stroke remains the leading cause of death and disability worldwide, and new effective treatments can complement existing treatments and extend the time window for treatment In this trial, neurostimulation therapy was safe and effective for patients who were not suitable for thrombotic treatment Future studies will further determine the effectiveness of new therapies in combination with thrombotic drugs or thrombosis devices Dr Jeffrey Saver, director of the UCLA Center for Integrated Stroke, who led the study , said, "We believe this represents the emergence of new treatments for acute cerebral infarction." "
References An injectable implant to the sphenopalatine ganglion for treatment of acute imicschae pheest to 24 h from onset (ImpACT-24B): an international, randomised, double-blind, sham-controlled, The Lancet, 10.1016/S0140-6736 (19) 31192-4 2 s option-feb-can can available new for most most stroke Retrieved May 27, 2019, from https:// , China Geriatrics Society Of Emergency Medicine, et al., (2 018) 2018 China Cardiovascular Disease Report 2017 The Carly of cardiovascular disease in China: feature currents and implications Nat Rev Cardiol 10.1038/s41569-018-0119-4 the original title - The Lancet: Just gently power! New treatment for cerebral infarction improves treatment rate and extends time window