New York City's COVID-19 originated in Europe and the United States, science study confirms

Introduction:since the outbreak of new crown pneumonia, the origin of the new crown virus has been the focus of attentionNew York City, the main "epicenter" of the new crown virus in the United States, has been the subject of a growing debate about the origin of its new crown virusA new study published recently in Science by the Icahn School of Medicine at Mount Sinai confirms that New York City's new coronavirus originated in Europe and the United Statesas of 17:30 BST on June 4, 2020, the cumulative number of confirmed cases in the United States 1902,031 people, 109,142 deaths, yesterday an increase of 21,365 peopleNew York State has the largest cumulative number of confirmed cases in the United States, with more than 200,000 confirmed casesthe first confirmed CASES OF COVID-19 in New York City came mainly from Europe and the United States, according to researchers brianne Ciferi, a doctoral student at the University of New York's School of Public Health at The Icahn School of Medicine at Mount S InaiNew York City has become one of the major epicenters of the SARS-CoV-2 infection in the United States, with nearly 17,000 deaths in metropolitan areasUnderstanding when the virus arrived in New York and how it spreads is critical to assessing and developing containment strategiesstudy, published May 29 in the journal Science, is the first to track the source of cases in New York City, and that the SARS-CoV-2 outbreak in New York City is most due to untraceable transmission between the United States and Europe, and there is no evidence to support the virus's introduction from China or other Asian countriesThe researchers also documented the early community spread of SARS-CoV-2 in New York City during this periodthe team sequenced the COVID-19 virus in patients treated at a hospital in Mount Sinai Health System, where they sought treatment at one of the Hospitals of mount Sinai Health SystemSystematic developmental analysis of 84 different SARS-CoV-2 genomes showed that multiple independent but isolated introductions came mainly from other parts of Europe and the United StatesThe researchers found clusters of the virus in patients living in different communities, suggesting that the spread of the community began on March 18Confirmed cases of SARS-CoV-2As of March 31, 2019, the number of patients who tested positive for the SARS-CoV-2 molecule was compared to the number of patients tested daily for influenza A and B in 2019-2020 The shaded area indicates the time at which samples sequenced in this study were obtained (February 29 to March 18) The number of positive tests for each virus is not standardized for the number of test samples the Pathogen Surveillance Program (PSP) at the Ikan School of Medicine at Mount Sinai is a multidisciplinary institutional infrastructure designed to generate high-resolution, near-real-time genetic information about pathogens A large number of patients seek treatment in the Mount Sinai Health System in New York City With the coding of biological specimens, nucleic acid extraction and qPCR quantification, a new generation sequencing technology based on Illumina and Pacific Biosciences technology provides information about the pathogen genome This process has been optimized to run quickly, data assembly is optimized, and the last important thing is that it integrates with identified demographic information for each specified branch, they identify different types of input events based on the sequence location in New York and the epidemiological information available The first virus isolate came from a patient with a history of travel exposure in the Middle East (A3, node 5), and the second isolated strain came from a patient with a history of travel in Europe (B, node 6) The vast majority (87%) of the remaining isolated strains are concentrated on A2a branches This branch consists mainly of isolated strains of newly crownpatients from Europe (72%), suggesting that the introduction of the virus from Europe was the subject of an outbreak in New York in the first week of March "Our research provides unexpected insights into the origin and diversity of this new viral pathogen," said Chiferi We have found clear evidence that different sources from all over the world and the United States have been able to introduce the metropolitan area independently on several occasions In addition, we have found strains in different communities throughout the city, suggesting that untracked community transmission began before March 18, and our findings underscore the need for an early public health response in the event of new pathogens It is hoped that the evidence we have found on early transmission and the introduction of national epicenters will guide future public health and contribute to the early stages of the pandemic "
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Lauren Source: Translational Medicine Network