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This article is original to Translational Medicine.
Please indicate the source Author: Sibyl Introduction: In order to completely eliminate tumors, Chinese researchers have developed a nanoplatform that can non-invasively eliminate solid liver cancer in mice with a 5-minute dose.
tumor
.
And the mice had no apparent side effects and all survived treatment for at least 30 days, a landmark development in animal cancer research models
.
They recently published the experimental results in Nano Research, titled "NIR-II photothermal therapy for effective tumor eradication enhanced by heterogeneous nanorods with dual catalytic activities"
.
https://link.
springer.
com/article/10.
1007/s12274-022-4096-x Professor Ding Ya from the Key Laboratory of Drug Quality Control and Safety Early Warning, China Pharmaceutical University, Ministry of Education, said: "For many years, tumor eradication has The dream of patients and researchers, preventing tumor recurrence and metastasis is also extremely important
.
However, due to the complexity, diversity and heterogeneity of tumors, it is impossible for a single treatment to completely eliminate them
.
Therefore, we aimed to design a Simple materials, or a simple system, to achieve the goal of collaboratively eradicating tumors
.
" Conventional treatments such as surgery and chemotherapy can cause some side effects and cause certain damage to healthy cells
.
Although some advanced therapies are less invasive and toxic, they are relatively conservative
.
So a treatment called photothermal therapy has attracted attention
.
The therapy involves injecting nanomaterials, especially gold nanorods, into the tumor and then activating it with a near-infrared second-region laser that humans cannot perceive
.
The laser causes the nanomaterial to emit heat, which kills cancer cells
.
Hou Yanglong, the author of the paper, director of the School of Materials Science and Engineering at Peking University and distinguished professor of Changjiang Scholar, said: "Photothermal therapy provides high temporal and spatial resolution for precise targeted therapy of tumors.
This therapy is non-invasive and has no toxic side effects.
It is a cancer treatment method that is very worthy of research
.
” Professor Hou also serves as the director of the Beijing Key Laboratory of Magnetoelectric Functional Materials and Devices at Peking University, and the deputy director of the Advanced Innovation Center for Engineering Science and Emerging Technologies at Peking University
.
"Despite these advantages, photothermal therapy often fails when it comes to treating large tumors
.
Therefore, our treatment regimen was designed based on its potential to address this problem one day
.
" Light frequencies in the near-infrared second region Higher, can irradiate deeper into the tumor, which requires the gold nanorods to have a higher aspect ratio
.
Such gold nanorods are more invasive but relatively less effective
.
So the researchers electroplated palladium clusters on both ends of the nanorods to improve their performance
.
The wavelength of light in the near-infrared second region is longer, which can activate the gold nanorods to a greater extent, so that they can react stably in deeper depths of cancer cells
.
This is the first function of the therapy
.
Second, the nanomaterials activate the prodrug of 5-fluorouracil, an intraperitoneally injected chemotherapeutic drug that is activated in situ in tumor cells (the drug is synthesized locally in the area where tumor cells form)
.
A third function for tumor eradication is that the nanomaterials can mimic the action of enzymes to convert hydrogen peroxide into reactive oxygen species
.
These free radicals can alter cellular persistence and proliferation mechanisms, forcing cells to autophagy upon signaling
.
Three functions of photothermal therapy, a three-pronged approach to cancer treatment Professor Ding said: "We made some structural changes to the nanorods, which greatly improved their ability to deal with complex diseases
.
This is a new type of therapeutic agent.
, is very effective for tumor therapy
.
" After that, the researchers will continue to explore how the nanoplatform interacts with healthy tissue, how it affects metabolism, and how it breaks down in the body after use
.
Professor Hou said: "There are several issues in this research project that have attracted our attention, and we will further develop simple, cheap, nanomaterials with high photothermal effect and high catalytic activity for clinical application
.
The current research bottleneck lies in , we hope to eradicate tumors in animals without toxic side effects
.
While photothermal therapy offers a solution, we still have a long way to go
.
"Reference: https:// .
org/news-releases/943353 Note: This article is intended to introduce medical research progress and is not intended to be used as a reference for treatment options
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·Events The First Yangtze River Delta Single Cell Omics Technology Application Forum [Webinar] Synthetic Biology Innovation and Development Popularity·Articles Stem Cell Research [Nature Sub-Journal] Using Stem Cells to Regenerate the Heart! Gene sequencing [Nature sub-journal] Analysis of 2658 complete DNA sequences - providing new clues for cancer mutations Cancer research [Science sub-journal] Will "lactic acid" help cancer cells? Studies have found that specific enzymes can fight it! Single-cell omics [guest announcement] The first Yangtze River Delta single-cell omics technology forum will be held in Shanghai in early March.
The important guests will be announced, and registration is free! The second issue of precision medicine "Precision Medicine" is coming! What kind of sparks can CAR-T and MRD collide with? Big coffee gathered to explain to you! Detection and diagnosis [Nature sub-journal] Fudan University Wei Dacheng's team and academician Liu Yunqi have developed an ultra-high-sensitivity detection portable device that can produce results in 4 minutes! PCR detection or be replaced!
Please indicate the source Author: Sibyl Introduction: In order to completely eliminate tumors, Chinese researchers have developed a nanoplatform that can non-invasively eliminate solid liver cancer in mice with a 5-minute dose.
tumor
.
And the mice had no apparent side effects and all survived treatment for at least 30 days, a landmark development in animal cancer research models
.
They recently published the experimental results in Nano Research, titled "NIR-II photothermal therapy for effective tumor eradication enhanced by heterogeneous nanorods with dual catalytic activities"
.
https://link.
springer.
com/article/10.
1007/s12274-022-4096-x Professor Ding Ya from the Key Laboratory of Drug Quality Control and Safety Early Warning, China Pharmaceutical University, Ministry of Education, said: "For many years, tumor eradication has The dream of patients and researchers, preventing tumor recurrence and metastasis is also extremely important
.
However, due to the complexity, diversity and heterogeneity of tumors, it is impossible for a single treatment to completely eliminate them
.
Therefore, we aimed to design a Simple materials, or a simple system, to achieve the goal of collaboratively eradicating tumors
.
" Conventional treatments such as surgery and chemotherapy can cause some side effects and cause certain damage to healthy cells
.
Although some advanced therapies are less invasive and toxic, they are relatively conservative
.
So a treatment called photothermal therapy has attracted attention
.
The therapy involves injecting nanomaterials, especially gold nanorods, into the tumor and then activating it with a near-infrared second-region laser that humans cannot perceive
.
The laser causes the nanomaterial to emit heat, which kills cancer cells
.
Hou Yanglong, the author of the paper, director of the School of Materials Science and Engineering at Peking University and distinguished professor of Changjiang Scholar, said: "Photothermal therapy provides high temporal and spatial resolution for precise targeted therapy of tumors.
This therapy is non-invasive and has no toxic side effects.
It is a cancer treatment method that is very worthy of research
.
” Professor Hou also serves as the director of the Beijing Key Laboratory of Magnetoelectric Functional Materials and Devices at Peking University, and the deputy director of the Advanced Innovation Center for Engineering Science and Emerging Technologies at Peking University
.
"Despite these advantages, photothermal therapy often fails when it comes to treating large tumors
.
Therefore, our treatment regimen was designed based on its potential to address this problem one day
.
" Light frequencies in the near-infrared second region Higher, can irradiate deeper into the tumor, which requires the gold nanorods to have a higher aspect ratio
.
Such gold nanorods are more invasive but relatively less effective
.
So the researchers electroplated palladium clusters on both ends of the nanorods to improve their performance
.
The wavelength of light in the near-infrared second region is longer, which can activate the gold nanorods to a greater extent, so that they can react stably in deeper depths of cancer cells
.
This is the first function of the therapy
.
Second, the nanomaterials activate the prodrug of 5-fluorouracil, an intraperitoneally injected chemotherapeutic drug that is activated in situ in tumor cells (the drug is synthesized locally in the area where tumor cells form)
.
A third function for tumor eradication is that the nanomaterials can mimic the action of enzymes to convert hydrogen peroxide into reactive oxygen species
.
These free radicals can alter cellular persistence and proliferation mechanisms, forcing cells to autophagy upon signaling
.
Three functions of photothermal therapy, a three-pronged approach to cancer treatment Professor Ding said: "We made some structural changes to the nanorods, which greatly improved their ability to deal with complex diseases
.
This is a new type of therapeutic agent.
, is very effective for tumor therapy
.
" After that, the researchers will continue to explore how the nanoplatform interacts with healthy tissue, how it affects metabolism, and how it breaks down in the body after use
.
Professor Hou said: "There are several issues in this research project that have attracted our attention, and we will further develop simple, cheap, nanomaterials with high photothermal effect and high catalytic activity for clinical application
.
The current research bottleneck lies in , we hope to eradicate tumors in animals without toxic side effects
.
While photothermal therapy offers a solution, we still have a long way to go
.
"Reference: https:// .
org/news-releases/943353 Note: This article is intended to introduce medical research progress and is not intended to be used as a reference for treatment options
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·Events The First Yangtze River Delta Single Cell Omics Technology Application Forum [Webinar] Synthetic Biology Innovation and Development Popularity·Articles Stem Cell Research [Nature Sub-Journal] Using Stem Cells to Regenerate the Heart! Gene sequencing [Nature sub-journal] Analysis of 2658 complete DNA sequences - providing new clues for cancer mutations Cancer research [Science sub-journal] Will "lactic acid" help cancer cells? Studies have found that specific enzymes can fight it! Single-cell omics [guest announcement] The first Yangtze River Delta single-cell omics technology forum will be held in Shanghai in early March.
The important guests will be announced, and registration is free! The second issue of precision medicine "Precision Medicine" is coming! What kind of sparks can CAR-T and MRD collide with? Big coffee gathered to explain to you! Detection and diagnosis [Nature sub-journal] Fudan University Wei Dacheng's team and academician Liu Yunqi have developed an ultra-high-sensitivity detection portable device that can produce results in 4 minutes! PCR detection or be replaced!
