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NICE recommends Merck's Tepmetko (tepotinib) for lung cancer

 Last Update: 2022-05-21
 Source: Internet
 Author: User

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The UK National Institute for Health and Care Excellence (NICE) recommends Tepmetko (tepotinib) for the treatment of adult patients with advanced non-small cell lung cancer ( NSCLC

Lung cancerNSCLC

Tepotinib is the first and only oral MET inhibitor recommended for the treatment of adult patients with advanced NSCLC with a METex14 skipping mutation for the NHS in England, Wales and Northern Ireland

Dr Shobhit Baijal, Consultant Medical Oncologist, University Hospitals NHS Trust, Birmingham, explained: "Existing treatment options for patients with METex14 skipping mutations often show limited progression-free survival and overall survival benefit

NSCLC is a heterogeneous disease with many genomic mutations

In an open-label phase II study, tepotinib (500 mg) was administered to patients with advanced or metastatic NSCLC with METex14 skipping mutations

In the combined biopsy group, the independently reviewed ORR was 46%, and the median duration of response was 11.

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