NNN: The relationship between overweight/obesity in young adults and EBV infection in the etiology of multiple sclerosis

Purpose: Since obesity affects the immune response of cells to infection, our purpose is to investigate whether high body mass index (BMI) and high Epstein-Barr nuclear antigen 1 (EBNA-1) antibody levels are related to the risk of multiple sclerosis (MS)
.

We also aim to explore the aspects of BMI, Epstein-Barr virus (EBV) infection (high EBNA-1 antibody levels and history of infectious mononucleosis [IM], respectively) at the age of 20, and human leukocyte antigen (HLA)-DRB1* 15:01 Potential relationship between alleles

Methods: A Swedish population-based case-control study (5460 cases and 7275 cases of control) was used to calculate the OR value (95% CIs) by logistic regression to evaluate overweight/obesity, IM history, EBNA-1 levels and HLA-DRB1 at the age of 20 *15:01 The relationship between MS risk
.

The potential interaction is evaluated on an additive scale

Results: Compared with normal weight, there is a significant correlation between overweight/obesity and high (>50th percentile) EBNA-1 antibody levels (the ratio caused by the interaction is 0.
2, 95% CI 0.
1-0.
4)
.

The higher the EBNA-1 antibody level, the stronger the interaction

Table 1 The confidence interval for multiple sclerosis in subjects with different combinations of body mass index and EBNA-1 antibody levels at the age of 20 is 95%

Table 1 The confidence interval for multiple sclerosis in subjects with different combinations of body mass index and EBNA-1 antibody levels at the age of 20 is 95%

Table 2 The 95% CI of OR for subjects with different combinations of HLA-DRB1*15:01 status, 20-year-old BMI and IM medical history

Table 2 The 95% CI of OR for subjects with different combinations of HLA-DRB1*15:01 status, 20-year-old BMI and IM medical history

Figure HLA-DRB1*15:01, overweight/obesity (>25 kg/m ² ), IM medical history and EBNA-1 status in different combinations of subjects compared with unexposed DRB1*15:01 negative subjects , The possibility of multiple sclerosis

Figure HLA-DRB1*15:01, overweight/obesity (>25 kg/m ² ), IM medical history and EBNA-1 status in different combinations of subjects compared with unexposed DRB1*15:01 negative subjects , The possibility of multiple sclerosis ²

Conclusion: In terms of MS risk, the two aspects of overweight/obesity in young adults and EBV infection have a synergistic effect, especially in people who are genetically susceptible to the disease
.

Obesity can not only induce chronic immune-mediated inflammation, but also affect the cellular immune response to infection

In terms of MS risk, the two aspects of overweight/obesity in young adults and EBV infection have a synergistic effect, especially in people who are genetically susceptible to the disease

Hedström AK, Brenner N, Butt J,et al, Overweight/obesity in young adulthood interacts with aspects of EBV infection in MS etiology.

Overweight/obesity in young adulthood interacts with aspects of EBV infection in MS etiology.
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