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    Home > Active Ingredient News > Study of Nervous System > No side effects, the effect surpasses morphine!

    No side effects, the effect surpasses morphine!

    • Last Update: 2021-11-05
    • Source: Internet
    • Author: User
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    Author of Big Data Digest: Mickey From ancient times to the present, human beings have been seeking suitable ways to fight pain
    .

    In order to relieve pain, people often turn to traditional painkillers
    .

    However, these drugs are often accompanied by various side effects, and long-term use also has the risk of addiction
    .

    Millions of people around the world are suffering from chronic pain.
    Long-term pain usually leads to inconvenience, anxiety, dependence on opioids and depression
    .

    Recently, scientists have made new progress in the study of pain relief
    .

    The Swedish researcher found that a major breakthrough has been achieved through a new personalized electrode brain implant technology that can relieve severe pain without the common side effects usually associated with analgesics
    .

    Severe chronic pain affects daily life.
    The side effects of traditional treatment methods are large.
    According to a study published by the Centers for Disease Control and Prevention of the United States, about 20% of the population suffers from chronic pain, and 8% of them suffer from serious illnesses that affect daily life
    .

    Chronic pain is related to many mental and physical problems.
    From the perspective of society as a whole, it is also one of the main factors leading to the decline of productivity and the high cost of medical care
    .

    Because of this, scientists have been seeking better ways to relieve pain
    .

    The most commonly used method of pain management is with the help of drugs
    .

    However, this method is usually accompanied by side effects and sometimes even produces dependence or addiction
    .

    Recently, a group of scientists at Lund University in Sweden developed a drug-free technology that can reduce pain by using ultra-thin, tissue-friendly microelectrodes for personalized stimulation
    .

    This research paper was recently published in "Science Progress", but the experiment has not yet been completed in humans.
    Researchers hope to be able to extend it to humans in the next 8 years
    .

    https:// Eliminates the side effects of pain: Compared with morphine, it has better effects and fewer side effects, the lead researcher of the paper and professor of neurophysiology Jens Schouenborg explained that the research The electrodes are very soft and very gentle on the brain
    .

    They can precisely activate the pain control center of the brain while avoiding the stimulation of nerve cells that produce side effects
    .

     During the experiment, the researcher will implant a set of ultra-thin electrodes into the brain
    .

    Then, carefully isolate specific electrodes that provide pure pain relief without side effects
    .

    This method can achieve extremely accurate and personalized stimulation therapy
    .

    Stop the pain by activating the pain control center of the brain, and then only block the signal transmission in the pain pathway to the cerebral cortex
    .

    Specifically, researchers have repeatedly tried to use this powerful analgesic control to treat patients with intractable pain by implanting deep brain stimulation (DBS) electrodes in PAG/DRN
    .

    Given that highly flexible and thin microelectrodes cause less severe tissue responses than rigid microelectrodes and can provide high-precision stimulation, they may help overcome the adverse effects that often occur with state-of-the-art simulation-based persistent pain treatments
    .

    However, due to the limited ability of thin microelectrodes to emit current, the accuracy of their placement is critical
    .

    In order to solve the problem of precise brain stimulation with minimal tissue response, researchers have developed a method of inserting highly flexible ultra-thin microelectrodes into deep brain targets
    .

    By embedding in needle-shaped, hard gelatin microelectrodes that swell during implantation and then dissolve, highly flexible microelectrodes can be implanted and spread out on deep brain targets
    .

    In this study, this design was further developed by introducing multi-level positions of de-insulated contacts, with the purpose of providing stimulation sites in the volume including PAG and DRN, thereby providing fine-tuning of nerve tissue in three dimensions (3D) , Particle stimulation provides a new paradigm
    .

    It is worth noting that the cluster design also reduces the problem of not knowing the precise location of the appropriate stimulation site in advance
    .

    The team succeeded in blocking pain almost completely without affecting any motor skills or sensory system
    .

    This method is far superior to morphine without the cognitive effects associated with morphine use
    .

    According to the data in the paper, the researchers compared PAG/DRN stimulation and morphine (1 mg/kg, subcutaneous injection) in the same animal (n = 8) for the same animal (n = 8) during the 4th to 5th week.
    To measure the analgesic effect of PAG/DRN cluster stimulation
    .

    Morphine-induced analgesia is not as strong as PAG/DRN stimulation
    .

    In addition, morphine caused obvious signs of behavioral sedation
    .

    For example, mice usually fall asleep when breathing slows down and closing their eyes
    .

    In addition, morphine also inhibited spontaneous neuronal activity in the S1 cortex, and there was no evidence of behavioral sedation or cortical activity suppression during PAG/DRN cluster stimulation.
    These results indicate that PAG/DRN cluster stimulation produces stronger production than morphine.
    The analgesic effect, and the side effects are smaller
    .

    Matilde Forni, the first author of the pain study, said: "Our results show that it is actually possible to develop powerful pain relievers with no side effects.
    This is a major challenge so far
    .

    " It is hoped that it will be applied to the human body within 8 years, and it is expected to treat Parkinson's and Depression However, this study in Lund was conducted on mice
    .

    So, can the results of this experiment be transferred to humans? Forni explained that they hope to apply the results to humans as soon as possible, because the control system of the human brain is equivalent to that of the mouse
    .

    According to Forni, the electrode design can be adjusted to suit humans
    .

     According to Jens Shouenborg, another author of the paper, the technique can in principle be applied to all parts of the brain
    .

    This means that it may not only be used to relieve pain, but also treat degenerative brain diseases like Parkinson's, as well as treat diseases such as epilepsy and depression
    .

     It is understood that these directions are currently trajectories to be explored, but first, Lund scientists said that in order to apply this technology to the clinic, the next step will be to increase the length and number of microelectrodes and necessary safety studies
    .

    It is hoped that their technology can provide treatment for individuals with severe chronic pain in less than 8 years
    .

     Related report: https:// people who click "watching" will look better!
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