Nobel Prize winner Michael Rosbash paper: Why fruit flies fly without calcium

dStim is essential to the nervous system during the early flight capability development of fruit flies. Richhariya et al.
is an important signaling substance that regulates a variety of cellular activity. Studies have shown that the development of fruit flies' flight ability can not be separated from the regulation of calcium in neurons. How is this process achieved? On February 14, 2017, Scientific Reports published an article called "
", which noted that calcium signals affect the development of flight ability early in the tick phase by regulating the expression of specific genes in neurons.
calcium enters cells in different modes and has different characteristics in time and space, which gives calcium signal specificity. What affects the fly's ability to fly is a calcium entry pattern called calcium pool manipulation calcium inflow (SOCE). SOCE transcription regulation in non-exciting cells has been well studied, and is rarely involved in the more complex calcium-powered conditions of nerve cells.
In order to understand the mechanism by which SOCE regulates the flight ability of fruit flies, Nobel Prize winner Michael Rosbash and colleagues sequenced the nervous system of fruit flies with RNA, narrowed the time range to the early stages of the tick phase, and discovered a key specific gene expression.
soCE in the nervous system is a major component called dStim, which is a calcium receptor in the endosuric web. The researchers found that dStim's lower regulation alters the expression of 131 genes, including a small GTP enzyme called Ral. When Ral in neurons is destroyed, the fly's ability to fly is also affected, while in SOCE-damaged neurons the hetero-expression Ral is regained. They also imaged real-time changes in calcium in in-body cultured radon neurons, confirming that Ral was not involved in SOCE, but played a role downstream.
results show that neuron SOCE is able to regulate the expression of specific genes during the development of the neural system, which is closely related to the maturation of flight neural circuits. (Source: Science.com)