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▎For the early management of type 2 diabetes by WuXi AppTec content team, in addition to controlling disease progression through existing therapies, it is also one of the directions to combine life>
.
The well-known DiRECT trial is a landmark study.
Among patients with type 2 diabetes with a short course of disease, intensive weight management through a low-calorie diet can help nearly half of the patients to get relief, and blood sugar control and insulin secretion can be achieved without taking medication.
Gradually return to normal
.
Recently, this research has made important progress again.
In addition to alleviating type 2 diabetes, dietary intervention can also effectively control the patient's blood pressure and stop or reduce the need for patients to take antihypertensive drugs
.
This latest result was published in Diabetologia, a journal of the European Diabetes Research Association
.
Screenshot source: Diabetologia.
The study was led by a research team from Glasgow and Newcastle University.
The researchers observed two cohorts.
The first cohort had 143 patients participating in diabetes relief intervention, and 78 of them took antihypertensive drugs at the beginning ( Among them, 44 took two or more drugs)
.
The second cohort had 69 patients who stopped antihypertensive drugs at the beginning
.
All subjects ate a low-calorie diet (825-853 kcal/day) for 12-20 weeks, and then readjusted their food for 2-8 weeks, and all received 12-hour training by a nutritionist and monthly follow-up and provision Relevant support to maintain weight loss
.
This diet reduces all nutrients including sodium, and the calories consumed by subjects within 12-20 weeks are significantly less than the basic energy expenditure, thereby achieving rapid weight loss
.
In addition, the researcher also regularly monitors the subjects' blood pressure and adjusts the medication according to the guidelines in time
.
The results found that, overall, in the 143 subjects who received dietary intervention, as weight loss, the average blood pressure decreased steadily
.
The overall average blood pressure of these subjects decreased significantly from the first week, and the blood pressure remained low at the 20th week, after the dietary intervention was completed, and the 12th and 24th months
.
Among 78 subjects who had previously been treated for hypertension, 65 (83%) discontinued all antihypertensive drugs and diuretics, and 4 (5%) discontinued some drugs
.
In the 69 subjects who stopped antihypertensive drugs at the beginning, their blood pressure did not change at first, but began to drop significantly after 9 weeks
.
During the calorie-restricted diet, 19 patients (27.
5%) restarted taking antihypertensive drugs although they did not record an excessive increase in blood pressure; including 5 subjects who had received a drug in the past and 14 patients who had received a drug in the past Subjects who have used two or more drugs
.
However, there are also 19 cases (27.
5%) who have not taken the drug at 24 months, that is, they can keep the drug off for at least two years
.
A total of 53 patients achieved sustained remission of diabetes (average weight loss of 11.
4 kg) at 24 months, and 31 of these patients had received treatment for hypertension
.
51 subjects had mild to moderate dizziness during the diet intervention replacement period, suggesting a certain degree of orthostatic hypotension.
Among them, 15 subjects recorded dizziness at the beginning, and 9 subjects received antihypertensive drugs or Diuretic treatment
.
Image source: 123RF Professor Mike Lean from the University of Glasgow pointed out: “At present, more than half of the 4.
5 million type 2 diabetes patients in the UK need to take antihypertensive drugs to reduce serious vascular complications
.
Being overweight is the main reason, so losing weight can relieve high blood pressure and diabetes
.
It is safe to stop antihypertensive drugs when the patient loses weight and regularly checks blood pressure
.
"Professor Roy Taylor from Newcastle University said: "The guidelines encourage doctors to start using drugs, but there is very little evidence to prove how to stop them
.
Most patients don’t like to take multiple drugs at the same time, so this research is very important.
We can reassure patients that when weight loss is achieved and maintained, it is possible for patients to effectively manage blood pressure and type 2 diabetes without taking drugs.
.
"The University of Glasgow's Dr.
Wilma Leslie added: "The study further emphasizes the link between diet, weight, type 2 diabetes and high blood pressure, and long-term support to maintain weight loss is essential
.
"Related reading EASD | Weight loss and reversal of type 2 diabetes add hope! The latest discovery of the milestone test can restore the shape of the pancreas "The Lancet" sub-Journal: Change bad habits as soon as possible, 60% of young patients with early diabetes are relieved, and 30% are reversed! Diabetes , Is it because the liver fat is too much to "overflow"?! The star trial "Cell" sub-publication reveals the new discovery of the Lancet: Weight loss reverses type 2 diabetes?! Heavy research is expected to change the status of treatment References: [1] Ahmad Al- Mrabeh, et al.
, (2019).
Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss.
Cell Metabolism, 10.
1016/j.
cmet.
2019.
11.
018[2] Diabetes remission diet also lowers blood pressure and reduces need for medication.
Retrieved 31-MAY-2021, from https:// Leslie, WS, Ali, E.
, Harris, L.
, Messow, CM, Brosnahan, NT, Thom, G.
, .
.
.
& Lean, ME (2021).
Antihypertensive needs and blood pressure control with weight medication loss in the Diabetes Remission Clinical Trial (DiRECT).
Diabetologia, 1-12.
Note: This article aims to introduce the progress of medical and health research, not to recommend treatment plans
.
If you need guidance on treatment plans, please go to a regular hospital for treatment
.
.
The well-known DiRECT trial is a landmark study.
Among patients with type 2 diabetes with a short course of disease, intensive weight management through a low-calorie diet can help nearly half of the patients to get relief, and blood sugar control and insulin secretion can be achieved without taking medication.
Gradually return to normal
.
Recently, this research has made important progress again.
In addition to alleviating type 2 diabetes, dietary intervention can also effectively control the patient's blood pressure and stop or reduce the need for patients to take antihypertensive drugs
.
This latest result was published in Diabetologia, a journal of the European Diabetes Research Association
.
Screenshot source: Diabetologia.
The study was led by a research team from Glasgow and Newcastle University.
The researchers observed two cohorts.
The first cohort had 143 patients participating in diabetes relief intervention, and 78 of them took antihypertensive drugs at the beginning ( Among them, 44 took two or more drugs)
.
The second cohort had 69 patients who stopped antihypertensive drugs at the beginning
.
All subjects ate a low-calorie diet (825-853 kcal/day) for 12-20 weeks, and then readjusted their food for 2-8 weeks, and all received 12-hour training by a nutritionist and monthly follow-up and provision Relevant support to maintain weight loss
.
This diet reduces all nutrients including sodium, and the calories consumed by subjects within 12-20 weeks are significantly less than the basic energy expenditure, thereby achieving rapid weight loss
.
In addition, the researcher also regularly monitors the subjects' blood pressure and adjusts the medication according to the guidelines in time
.
The results found that, overall, in the 143 subjects who received dietary intervention, as weight loss, the average blood pressure decreased steadily
.
The overall average blood pressure of these subjects decreased significantly from the first week, and the blood pressure remained low at the 20th week, after the dietary intervention was completed, and the 12th and 24th months
.
Among 78 subjects who had previously been treated for hypertension, 65 (83%) discontinued all antihypertensive drugs and diuretics, and 4 (5%) discontinued some drugs
.
In the 69 subjects who stopped antihypertensive drugs at the beginning, their blood pressure did not change at first, but began to drop significantly after 9 weeks
.
During the calorie-restricted diet, 19 patients (27.
5%) restarted taking antihypertensive drugs although they did not record an excessive increase in blood pressure; including 5 subjects who had received a drug in the past and 14 patients who had received a drug in the past Subjects who have used two or more drugs
.
However, there are also 19 cases (27.
5%) who have not taken the drug at 24 months, that is, they can keep the drug off for at least two years
.
A total of 53 patients achieved sustained remission of diabetes (average weight loss of 11.
4 kg) at 24 months, and 31 of these patients had received treatment for hypertension
.
51 subjects had mild to moderate dizziness during the diet intervention replacement period, suggesting a certain degree of orthostatic hypotension.
Among them, 15 subjects recorded dizziness at the beginning, and 9 subjects received antihypertensive drugs or Diuretic treatment
.
Image source: 123RF Professor Mike Lean from the University of Glasgow pointed out: “At present, more than half of the 4.
5 million type 2 diabetes patients in the UK need to take antihypertensive drugs to reduce serious vascular complications
.
Being overweight is the main reason, so losing weight can relieve high blood pressure and diabetes
.
It is safe to stop antihypertensive drugs when the patient loses weight and regularly checks blood pressure
.
"Professor Roy Taylor from Newcastle University said: "The guidelines encourage doctors to start using drugs, but there is very little evidence to prove how to stop them
.
Most patients don’t like to take multiple drugs at the same time, so this research is very important.
We can reassure patients that when weight loss is achieved and maintained, it is possible for patients to effectively manage blood pressure and type 2 diabetes without taking drugs.
.
"The University of Glasgow's Dr.
Wilma Leslie added: "The study further emphasizes the link between diet, weight, type 2 diabetes and high blood pressure, and long-term support to maintain weight loss is essential
.
"Related reading EASD | Weight loss and reversal of type 2 diabetes add hope! The latest discovery of the milestone test can restore the shape of the pancreas "The Lancet" sub-Journal: Change bad habits as soon as possible, 60% of young patients with early diabetes are relieved, and 30% are reversed! Diabetes , Is it because the liver fat is too much to "overflow"?! The star trial "Cell" sub-publication reveals the new discovery of the Lancet: Weight loss reverses type 2 diabetes?! Heavy research is expected to change the status of treatment References: [1] Ahmad Al- Mrabeh, et al.
, (2019).
Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss.
Cell Metabolism, 10.
1016/j.
cmet.
2019.
11.
018[2] Diabetes remission diet also lowers blood pressure and reduces need for medication.
Retrieved 31-MAY-2021, from https:// Leslie, WS, Ali, E.
, Harris, L.
, Messow, CM, Brosnahan, NT, Thom, G.
, .
.
.
& Lean, ME (2021).
Antihypertensive needs and blood pressure control with weight medication loss in the Diabetes Remission Clinical Trial (DiRECT).
Diabetologia, 1-12.
Note: This article aims to introduce the progress of medical and health research, not to recommend treatment plans
.
If you need guidance on treatment plans, please go to a regular hospital for treatment
.
