npj Parkinsons Dis: Degree of constipation that predicts clinical outcomes in Parkinson's patients

Although Parkinson's disease (PD) is characterized by dyskinesia, it is associated with distinct non-motor features, including gastrointestinal (GI) dysfunction such as constipation, dysphagia, hypersalivation, delayed gastric emptying, and regurgitation flow

Although Parkinson's disease (PD) is characterized by dyskinesia, it is associated with distinct non-motor features, including gastrointestinal (GI) dysfunction such as constipation, dysphagia, hypersalivation, delayed gastric emptying, and regurgitation flow

Figure 1: Paper title map

Figure 1: Paper title map

Research efforts on the gut-brain axis have greatly increased, and there is growing evidence that gut dysfunction may play a role in the early pathogenesis of PD; however, its link to disease progression has been underrepresented attention

Research efforts on the gut-brain axis have greatly increased, and there is growing evidence that gut dysfunction may play a role in the early pathogenesis of PD; however, its link to disease progression has been underrepresented attention

Figure 2: Constipation affects clinical outcomes

Figure 2: Constipation affects clinical outcomes

With this, M.

With this, M.

Constipation is assessed by the MDS-UPDRS Constipation Item or a similar categorical scale

The primary PD outcomes of interest were dementia, postural instability, and death

PD patients were stratified according to the severity of constipation at diagnosis

After adjusting for relevant confounders, Cox regression analysis confirmed a significant association between constipation severity and dementia progression, but not postural instability or death

Thus, early constipation may herald the accelerated development of neurodegenerative disease

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