npj Parkinsons Dis: How does white matter structure change in early tremor-dominant Parkinson's?

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by predominant motor symptoms, including stiffness, resting tremor, and bradykinesia, manifested by selective loss of dopaminergic neurons in the substantia nigra and alpha- Synapsin is widely aggregated in the form of Lewy neurons and Lewy bodies

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by predominant motor symptoms, including stiffness, resting tremor, and bradykinesia, manifested by selective loss of dopaminergic neurons in the substantia nigra and alpha- Synapsin is widely aggregated in the form of Lewy neurons and Lewy bodies

It has been argued that TD-PD and PIGD-PD have inconsistent patterns of clinical progression

It has been argued that TD-PD and PIGD-PD have inconsistent patterns of clinical progression

Diffusion tensor imaging (DTI) is currently the most widely used method to estimate changes in WM microstructural integrity in PD

Fractional anisotropy corresponds to the degree of orientation of water diffusion, reflecting the integrity of white matter

The inability to resolve the multiple fiber orientations of intersecting or kissing fiber regions, which include up to 90% of WM voxels in the brain, can lead to unreliable estimates of DTI measurements in these regions

Advances in diffusion modeling techniques allow the quantification of WM fiber properties in the presence of complex fiber geometries

Briefly, FBA utilizes fiber orientation distributions (FODs) estimated by constrained spherical deconvolution (CSD), enabling measurement of microstructural differences in fiber density (FD), macroscopic fiber bundle cross-sections (FC) Structural differences or differences resulting from the combination of FD and FC (fiber density and cross-section [FDC])

In the developing brain, the increase in fixel may be due to an increase in axonal diameter or axonal number, while the decrease in these indicators may be due to axonal loss or atrophy, as in PD

Whether the WM microstructural changes detected in early PD, especially TD-PD (as measured by increased FA) detected on DTI, reflect selective neurodegenerative or compensatory mechanisms, remains unknown

In the current cross-sectional study, Christina Andica et al.

Using FBA-based, they assessed fiber-specific white matter (WM) changes in drug-naive patients with early Parkinson's disease (PD), who were predominantly tremor (TD; n = 53; mean age, 61.

Using FBA-based, they assessed fiber-specific white matter (WM) changes in drug-naive patients with early Parkinson's disease (PD), who were predominantly tremor (TD; n = 53; mean age, 61.

FBA revealed a significant increase in the cross-section of large structural fibers within the corticospinal tract and the combination of fiber density and cross-sectional metrics in TD-PD patients

However, no significant changes were found in FBA-derived measures in PIGD-PD patients compared with HC or TD-PD patients

These results provide: Evidence for WM neurocompensatory mechanisms in TD-PD patients marked by increased fiber tract size and the ability to transmit information between brain regions
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Evidence for WM neurocompensatory mechanisms in TD-PD patients

Source:
Andica C, Kamagata K, Saito Y, et al.
Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson's disease.
npj Parkinsons Dis .
2021;7(1):51.
doi:10.
1038/s41531- 021-00197-4

Source:
Andica C, Kamagata K, Saito Y, et al.
Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson's disease.
npj Parkinsons Dis .
2021;7(1):51.
doi:10.
1038/s41531- 021-00197-4 Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson's disease.
npj Parkinsons Dis

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