npj Parkinsons Dis: Integrating 4 million clinical data in the UK, what are the characteristics of the incidence of Parkinson's?

The prevalence of Parkinson's disease (PD) has increased globally over the past 20 to 30 years
.

This is at least partly related to the increase in life expectancy over this period in most countries

The prevalence of Parkinson's disease (PD) has increased globally over the past 20 to 30 years

Figure 1 Title of the paper

Figure 1 Title of the paper

It has been speculated that an increase in risk factors for PD may account for this increase
.

However, there are few incidence studies evaluating the same population with similar determinations at different time points, as it is difficult to identify PD patients in a stable, generalizable population

It has been speculated that an increase in risk factors for PD may account for this increase

Most studies were cross-sectional, assessed prevalence, and could not account for changes in diagnostic patterns

Using electronic medical records with appropriate case confirmation, trends in PD over time can be explored in a consistent manner

Due to the routine collection of data when recording PD diagnoses in the database, the problem of underreporting due to selection bias is mitigated

The validity of important diagnoses in primary care databases is high

In addition, important diagnoses of long-term disease have been shown to have good specificity and sensitivity in primary care records

Therefore, to determine changes in the incidence of PD in the UK, Olaitan Okunoye et al at UCL UK studied age-adjusted incidence of PD in the UK primary care database, using the same confirmation method over time, using several definitions to illustrate the diagnosis Pattern changes over time

They conducted a cohort study of individuals aged ≥50 years in a large UK primary care database between January 2006 and December 2016

To account for possible changes in diagnostic patterns, they calculated the incidence of PD using four case definitions of varying stringency, derived from a combination of PD diagnosis, symptoms, and treatment

Figure 2 Results of the incidence of PD

Figure 2 Results of the incidence of PD

Using the most widely used case definition, the incidence rate (IR) per 100,000 person-years at risk was 149 (95% CI 143.
3-155.
4) in 2006 and 144 (95% CI 136.
9-150.
7) in 2016
.

Using the most widely used case definition, the incidence rate (IR) per 100,000 person-years at risk was 149 (95% CI 143.
3-155.
4) in 2006 and 144 (95% CI 136.
9-150.
7) in 2016
.

In conclusion , when age and diagnostic patterns were taken into account, the incidence of PD in the UK remained stable between 2006 and 2016, suggesting no major changes in underlying risk factors for PD in the UK during this period
.

In conclusion , when age and diagnostic patterns were taken into account, the incidence of PD in the UK remained stable between 2006 and 2016, suggesting that there have been no major changes in the underlying risk factors for PD in the UK during this period
.

 

Original source:

Original source:

Okunoye O, Marston L, Walters K, Schrag A.
Change in the incidence of Parkinson's disease in a large UK primary care database.
npj Parkinsons Dis.
2022;8(1):23.
doi:10.
1038/s41531-022-00284- 0

Okunoye O, Marston L, Walters K, Schrag A.
Change in the incidence of Parkinson's disease in a large UK primary care database.
npj Parkinsons Dis.
2022;8(1):23.
doi:10.
1038/s41531-022-00284- 0 Change in the incidence of Parkinson's disease in a large UK primary care database.
npj Parkinsons Dis.

 

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