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Parkinson's disease, the second most common neurodegenerative disease, is pathologically characterized by progressive degeneration of dopaminergic neurons in the substantia nigra
Parkinson's disease, the second most common neurodegenerative disease, is pathologically characterized by progressive degeneration of dopaminergic neurons in the substantia nigra
Figure 1 Title map of the paper
Figure 1 Title map of the paperCurrently, there is compelling evidence that inflammation and immunity play important roles in the pathogenesis of PD, and comorbidities between PD and autoimmune diseases have been reported
Currently, there is compelling evidence that inflammation and immunity play important roles in the pathogenesis of PD, and comorbidities between PD and autoimmune diseases have been reported
Traditionally, rheumatoid arthritis has been associated with an increased risk of PD because of overproduction of inflammatory mediators and overactivation of immune cells
However, recent cohort studies have shown a reduced risk of PD in patients with rheumatoid arthritis, contrary to previous results
Therefore, whether rheumatoid arthritis affects the risk of PD remains unknown
The Mendelian random method uses single nucleotide polymorphisms as the instrumental variables of exposure, so it can effectively avoid the interference factors caused by changes in related traits, and has high scientific value
In this way, in order to explore the potential causal relationship between rheumatoid arthritis and PD, ChunYu Li et al.
They first analyzed the genetic association between PD and rheumatoid arthritis and detected significant and negative genetic associations genome-wide
The effect of rheumatoid arthritis on PD risk was then analyzed using MR methods
They found that every one standard deviation increase in rheumatoid arthritis risk was associated with a lower risk of PD, a finding that was supported by three additional MR methods, MR-Egger regression, weighted mode, and weighted median
The funnel plot shows a symmetrical pattern of effect size variation around the point estimates
The simple median method did not show a clear association, but suggested the same direction of effect
They further replicated the results with the IVW approach using exposure from another large GWAS for rheumatoid arthritis
They first estimated the genetic association between rheumatoid arthritis and PD, and then doubled it based on summary statistics from a large genome-wide association study of rheumatoid arthritis (N = 47,580) and PD (N = 482,703).
them
Figure 2 The relationship between PD and rheumatoid
Figure 2 The relationship between PD and rheumatoidThey found a negative and significant correlation between rheumatoid arthritis and Parkinson's disease (genetic correlation: -0.
10, P = 0.
0033)
.
10, P = 0.
0033)
.
Negative and significant association between rheumatoid arthritis and Parkinson's disease
At the same time, an increased risk of rheumatoid arthritis by one standard deviation was associated with a reduced risk of PD (OR: 0.
904, 95% CI: 0.
866-0.
943, P: 2.
95E-06)
.
This result was robust across all sensitivity analyses
.
904, 95% CI: 0.
866-0.
943, P: 2.
95E-06)
.
This result was robust across all sensitivity analyses
.
These findings: Provide evidence supporting a protective effect of rheumatoid arthritis on PD
.
A better understanding of inflammation and immune responses may shed light on the underlying pathogenesis of PD and identify therapeutic targets for PD
.
.
A better understanding of inflammation and immune responses may shed light on the underlying pathogenesis of PD and identify therapeutic targets for PD
.
Provided evidence supporting a protective effect of rheumatoid arthritis on PD
.
Original source:
Li C, Ou R, Shang H .
Rheumatoid arthritis decreases risk for Parkinson's disease: a Mendelian randomization study.
npj Parkinsons Dis.
202 1;7(1):17.
doi:10.
1038/s41531-021-00166-x
Original source:
Li C, Ou R, Shang H .
Rheumatoid arthritis decreases risk for Parkinson's disease: a Mendelian randomization study.
npj Parkinsons Dis.
202 1;7(1):17.
doi:10.
1038/s41531-021-00166-x .
Rheumatoid arthritis decreases risk for Parkinson's disease: a Mendelian randomization study.
npj Parkinsons Dis.
202
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