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Although Parkinson's disease (PD) is characterized by dyskinesia, it is associated with significant non-motor features such as gastrointestinal (GI) dysfunction, such as constipation, dysphagia, saliva leakage, delayed gastric emptying, and reflux.
prevention
Camacho, M.
Camacho, M.
The study analyzed data from the Parkinson’s Disease Incidence Cohort Collaborative Organization, which consists of a community-based cohort of Parkinson’s disease patients for an 8-year period.
The values shown are mean ± standard deviation and (range).
The values shown are mean ± standard deviation and (range).
diagnosis
In patients with more severe constipation at baseline, the clinical progression of the three outcomes was faster (Kaplan-Meier survival analysis).
According to the severity of constipation, the survival analysis of the main prognosis of Parkinson's disease
According to the severity of constipation, the survival analysis of the main prognosis of Parkinson's diseaseAfter adjusting for related confounding factors, Cox regression analysis confirmed that there was a significant correlation between the severity of constipation and the progression of dementia, but it was not related to postural instability or death.
Cox regression model of the predictive effect of constipation severity on postural instability, dementia and death after adjusting for covariates
After adjusting for covariates, the Cox regression model of the predictive effect of constipation severity on postural instability, dementia, and death After adjusting the covariates , the Cox regression model of predicting the predictive effect of constipation severity on postural instability, dementia, and death After adjusting for covariates , Cox regression model of the predictive effect of constipation severity on postural instability, dementia and deathThe study investigated the relationship between early constipation and subsequent disease progression in a representative population of community-based PD cases, demonstrating that the severity of constipation at the onset of disease predicts faster progression to dementia .
The severity of constipation at the onset of the disease predicts a faster progression to dementia The severity of the constipation at the onset of the disease predicts a faster progression to dementia
In summary, the results of this study support the importance of studying constipation in PD patients, indicating that the appearance and severity of constipation symptoms at the time of diagnosis can predict subsequent dementia progression.
The results of this study support the importance of studying constipation in PD patients, indicating that the appearance and severity of constipation symptoms at the time of diagnosis can predict subsequent dementia progression.
Camacho, M.
Camacho, M.
, Macleod, AD, Maple-Grødem, J.
et al.
Early constipation predicts faster dementia onset in Parkinson's disease.
npj Parkinsons Dis.
7, 45 (2021).
https://doi.
org/10.
1038/s41531 -021-00191-w Camacho, M.
, Macleod, AD, Maple-Grødem, J.
et al.
npj Parkinsons Dis.
7,
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