Npj Vaccines: Under-skin vaccination helps prevent respiratory diseases

January 28, 2021 /--- - --- is a successful example of human success in the fight against infectious diseases, which we eradicated as early as the 20th century through vaccination.
until recently, the flux vaccine was given using a technique called skin scratching, s.s., which requires repeatedly scraping the skin with a needle before vaccination.
, almost all other vaccines are now available through intramuscular injections.
Thomas Kupper, head of the Department of Dermatology, and colleagues have reason to suspect that vaccination with skin scratches may better prevent respiratory diseases.
a study published in npj Vaccines, Kupper et al. presented the results of preclinical studies that suggest that skin scratches may help produce lung T cells and provide protection against infectious diseases, which is important for preventing COVID-19.
today's vaccine development focuses on selecting the best antigens for T- and B-cells, said Kupper, who created the vaccine (Photo source: www.pixabay.com).
, however, vaccines need to direct T-cells where they are needed most if they are to reach their full potential.
for respiratory pathogens, which means transporting T-cells to the lungs.
Kupper and his colleagues set out to determine whether MVA-based skin scratch immunization methods could cause more effective T-cell responses than other immunization methods.
the team inoculated mice with skin scratches, intramuscular injections, intraskinal injections or intra-skin injections.
results show that skin scratches produce more T-cells, produce more lung-specific T-cells, and provide better protection against lethal doses of the virus than other drugs.
Kupper said: "We used to think that T cells that came home from the lungs could only be produced by direct lung infections, but here we found that there was overlap between T cells that appeared after lung infections and T cells produced through scratches on the skin.
authors note that it is not clear whether the phenomena seen in mouse models can be replicated in the human body.
but this work has stimulated Kupper's lab to explore the potential to use MVA vectors and skin scratch technology to develop more powerful (and even potentially universal) vaccines against other infectious diseases such as influenza and coronavirus.
(Bioon.com) Source: Vaccine delivered via skin help in fight against the raw source of the disease: Youdong Pan et al, Epicutaneous immunization with modified vaccinia technology vectors generates superiors cell immunity against a sacry viral challenge, npjAnkara Vaccines (2021). DOI: 10.1038/s41541-020-00265-5