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After maintaining zero local malaria cases for three consecutive years, China applied for malaria-free certification from the World Health Organization (WHO) last year.
However, looking at the world, malaria is still a major public health problem facing the world.
The pathogen of malaria is Plasmodium.
On August 8, 2021, Tongji University and Jiangsu Institute of Parasitic Disease Control jointly published an article entitled "A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum" in the international journal Nucleic Acids Resreach, revealing The core regulator of malaria transmission
First, the research team used CRISPR-Cas9 gene editing technology to carry out systematic gene knockout and gametophyte production ability screening of the P.
Functional screening of ApiAP2 family for gametophyte production
Functional screening of ApiAP2 family for gametophyte production Functional screening of ApiAP2 family for gametophyte productionSubsequently, the researchers studied the function and mechanism of PfAP2-G5.
PfAP2-G5 inhibits the transcriptional activity of pfap2-g gene
PfAP2-G5 inhibits the transcriptional activity of pfap2-g gene PfAP2-G5 inhibits the transcriptional activity of pfap2-g geneFinally, the researchers also proved through experiments that PfAP2-G5 also plays an important role in the development of early gamete cells.
Experimental mechanism diagram
Experimental mechanism diagram Experimental mechanism diagramIn conclusion, this article found that PfAP2-G5 is indispensable in gametogenesis
Original source:
Original source:Xiaomin Shang, Shijun Shen, Jianxia Tang, et al.
A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum.
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