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    Home > Active Ingredient News > Infection > Nucleic Acids Research: Chinese scientists discover core regulators of malaria transmission

    Nucleic Acids Research: Chinese scientists discover core regulators of malaria transmission

    • Last Update: 2021-09-10
    • Source: Internet
    • Author: User
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    After maintaining zero local malaria cases for three consecutive years, China applied for malaria-free certification from the World Health Organization (WHO) last year.


    However, looking at the world, malaria is still a major public health problem facing the world.


    The pathogen of malaria is Plasmodium.


    On August 8, 2021, Tongji University and Jiangsu Institute of Parasitic Disease Control jointly published an article entitled "A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum" in the international journal Nucleic Acids Resreach, revealing The core regulator of malaria transmission


    First, the research team used CRISPR-Cas9 gene editing technology to carry out systematic gene knockout and gametophyte production ability screening of the P.


    Functional screening of ApiAP2 family for gametophyte production

    Functional screening of ApiAP2 family for gametophyte production Functional screening of ApiAP2 family for gametophyte production

    Subsequently, the researchers studied the function and mechanism of PfAP2-G5.


    PfAP2-G5 inhibits the transcriptional activity of pfap2-g gene

    PfAP2-G5 inhibits the transcriptional activity of pfap2-g gene PfAP2-G5 inhibits the transcriptional activity of pfap2-g gene

    Finally, the researchers also proved through experiments that PfAP2-G5 also plays an important role in the development of early gamete cells.


    Experimental mechanism diagram

    Experimental mechanism diagram Experimental mechanism diagram

    In conclusion, this article found that PfAP2-G5 is indispensable in gametogenesis


    Original source:

    Original source:

    Xiaomin Shang, Shijun Shen, Jianxia Tang, et al.


    A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum.


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