Often "early satiety", "diarrhea"? It may be a diabetic ghost

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Introduction: Often "early satiety", "diarrhea"? It may be a diabetic "trickster"!

Gastrointestinal disorders are influenced by lifestyle and psychological factors, however, one study found that diabetes is an independent risk factor for precocious diarrhea, which is the result of excluding the above two related factors, according to the findings published in Neurogastroenterology & Motility
.

The study was based on the results of two survey studies, 1900 people in study 1 completed the baseline survey and the one-year follow-up survey; In study 2, 1322 people completed the baseline survey and the three-year follow-up survey
.
The survey included the occurrence of diabetes and gastrointestinal symptoms in the past 3 months, and assessed psychological, lifestyle factors (BMI, smoking), and age and gender
.

Diabetes is independently associated with gastrointestinal-related symptoms

At baseline, the prevalence of diabetes in studies 1 and 2 was 7.
8% and 8.
9%, respectively;

Diabetes is an independent predictor of satiety and diarrhea:

➤ Satiety correlation (OR 1.
58, 95% CI 1.
05 to 2.
39, P=0.
03; OR 1.
67, 95% CI 1.
14-2.
45, P=0.
009);

➤ Diarrhoea was associated (OR 1.
44, 95% CI 1.
06 to 1.
95, P=0.
02; OR 2.
17, 95% CI 1.
47-3.
22, P=0.
0001), based on multivariate models including age, sex, BMI, anxiety, depression
, etc.

Independent predictors of gastrointestinal symptoms following diabetes mellitus after 1 and 3 years of follow-up:

➤ Number of bowel movements > 3 times per day (OR 1.
50, 95% CI 1.
08-2.
07, P=0.
02; OR=1.
67, 95%CI 1.
11-2.
51, P=0.
01);

➤ Fecal non-forming (OR 1.
40, 95% CI 1.
04-1.
90, P=0.
03; OR=1.
68, 95%CI 1.
13-2.
51; P=0.
01).

These results persisted
after adjusting for glycemic control factors.
Diabetes was also found to be not independently associated with constipation, abdominal pain, or bloating, or due to
other factors.

brief summary

Both studies have demonstrated diabetes as an independent risk factor for frequent early satiety and diarrhoea, a finding that may provide a valuable reference
for understanding the causes and management of diabetes.

References: Koloski NA, Jones M, Walker MM, Horowitz M, Holtmann G, Talley NJ.
Diabetes mellitus is an independent risk factor for a greater frequency of early satiation and diarrhea at one and three years: Two prospective longitudinal population-based studies [published online ahead of print, 2022 Oct 10].
Neurogastroenterol Motil.
2022; e14471.
doi:10.
1111/nmo.
14471