Older age during pregnancy, childbearing and menopause, lower risk of dementia in women

Dementia rates are on the rise around the world, with some studies reporting higher rates in women than in men, but there is limited evidence on reproductive factors and dementia risk
.

After controlling for age, socioeconomic status, smoking, body mass index (BMI), and other elements, certain events were associated with shorter cumulative exposure to internal estrogen production, such as older than average age in the first stage, and lower than average age at menopause Being younger and having a hysterectomy is associated with a higher risk of dementia
.

The study has limitations, including a retrospective report on reproductive factors that could be biased, and the fact that the UK Biobank is a relatively healthy affluent population of white British ancestry and therefore may not be representative of the wider population
.

Gong added: "Reproductive activity with shorter exposure to endogenous estrogens in women is associated with a higher risk of dementia, and these findings underscore the vulnerability of women to dementia risk
.

Journal Reference :

1. Jessica Gong, Katie Harris, Sanne AE Peters, Mark Woodward.