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    Home > Chemicals Industry > Chemical Technology > Oleanolic acid

    Oleanolic acid

    • Last Update: 2022-06-12
    • Source: Internet
    • Author: User
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    Oleanolic acid

    Oleanolic acid

    [Synonyms] Angelica sinensis , Oleanol, CaryopHyllin, Asstrantiagenin C, Giganteumgenin C, Virgaureagenin B

    【Structural formula】

    [Molecular formula and molecular weight] C 30 H 48 O 3 ; 456.
    70

    [Source] The dried and mature pulp of Cornus of ficinalis
    .

    【Properties】White powder
    .

    This product is insoluble in water, but soluble in methanol , ethanol , ether , acetone and chloroform
    .

    Melting point: The melting point is greater than 300°C
    .

    Optical rotation: [α]D 20 +73.
    3°(C0.
    15, CHCl 3 )
    .

    【Purity Check】

    TLC

    1.
    Thin layer plate silica gel G

    Developing agent chloroform- methanol (40:1)

    Check the color development of 10% sulfuric acid ethanol solution, heating at 105℃, inspection under ultraviolet light (254nm, 365nm) and sunlight

    2.
    Thin layer plate silica gel G

    Developing agent cyclohexane-chloroform- ethyl acetate - formic acid (20:5:8:0.
    1)

    Check the color development of 10% sulfuric acid ethanol solution, heating at 105℃, inspection under ultraviolet light (254nm, 365nm) and sunlight

    High performance liquid chromatography

    Column CapCell Pack C 18 , 5um (4.
    6mm×250mm)

    Mobile phase acetonitrile-0.
    1% phosphoric acid (75:25), 1.
    0ml/min

    Detection wavelength 210nm

    【Structural identification】203
    .

    3406, 2943, 2862, 1695, 1464, 1387, 1032, 997
    .

    EI-MS m/z: 456[M] + , 248, 207, 203, 189, 133
    .

    1 H-NMR (C 5 D 5 N) δ: 0.
    88, 1.
    02, 1.
    05, 1.
    22, 1.
    24 (3Heach, s, 5×CH 3 ), 0.
    94, 1.
    01 (3Heach, s, 2×CH 3 )
    .

    13 C-NMR (C 5 D 5 N) δ: 38.
    6(C-1), 27.
    3(C-2), 79.
    1(C-3), 38.
    8(C-4), 55.
    4(C-5), 18.
    4( C-6), 33.
    1(C-7), 39.
    4(C-8), 47.
    8(C-9), 37.
    2(C-10), 23.
    6(C-11), 122.
    7(C-12), 143.
    6(C -13), 41.
    7(C-14), 27.
    8(C-15), 23.
    1(C-16), 46.
    6(C-17), 41.
    2(C-18), 46.
    0(C-19), 30.
    7(C- 20), 33.
    9(C-21), 32.
    8(C-22), 28.
    2(C-23), 15.
    5(C-24), 15.
    3(C-25), 17.
    2(C-26), 25.
    9(C-27) ), 183.
    0(C-28), 32.
    5(C-29), 23.
    5(C-30)
    .

    【Storage】Dry and airtight
    .

     

     

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