Oligonucleoside Boranophosphate (Borane Phosphonate)
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Last Update: 2020-12-10
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Source: Internet
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Author: User
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A number of short modified synthetic oligodeoxynucleotides have shown promise as agents for gene therapy (
1
–
8
). Among these, two classes of oligonucleotides with modified backbones (the phosphorothioates [
9
] and methylphosphonates [
10
]) have emerged as primary candidates. We have synthesized another homologous type of nucleotide called a boranophosphate, or borane phosphonate (
11
), which can be viewed as a “hybrid” of two types of oligonucleotide molecules, i.e., the normal phosphodiester and the methylphosphonate (
see
Fig. 1 ). In addition, the boranophosphate is negatively charged like the phosphorothioate, another well-studied antisense agent.Fig. 1.
Internucleotide linkage modifications.
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