OMCL: Increased serum fetuin-B levels in women with metabolic syndrome are associated with increased oxidative stress

Background: The relationship between serum fetuin-B (fetuin-like protein IRL685) and T2 DM has been studied in the past, but the reasons for changes in serum fetuin-B and its regulatory factors in metabolic diseases are still unclear
.

The relationship between serum fetuin-B (fetuin-like protein IRL685) and T2 DM has been studied in the past, but the reasons for changes in serum fetuin-B and its regulatory factors in metabolic diseases are still unclear
.

Purpose: Here, we assessed the serum fetoglobulin B level of newly diagnosed patients with alpha-fetoprotein syndrome and conducted various interventions to explore the role of fetuin-B in the pathogenesis of alpha-fetoprotein syndrome
.

Methods: Enzyme-linked immunosorbent assay (ELISA) was used to determine the serum fetuin-B (FB) level
.

Bioinformatics methods were used to analyze fetuin B-related genes and signal transduction pathways

Results: We found that compared with healthy people, women with metabolic syndrome had significantly higher serum fetuin-B levels
.

In addition, serum fetuin-B is positively correlated with waist-to-hip ratio, fat percentage, triglycerides, fasting blood glucose, glycosylated hemoglobin, FINS, HOMA-IR, VAI and LAP

Figure 1 Bioinformatics analysis related to fetuin-B
.

(A) The PPI network uses the keyword FETUB related to metabolism

Figure 1 Bioinformatics analysis related to fetuin-B

Figure 2 Fetuin-B aggravated the oxidative stress induced by free fatty acids in HepG2 cells
.

The HepG2 cells were transfected with pcDNA3.

Figure 2 Fetuin-B aggravated the oxidative stress induced by free fatty acids in HepG2 cells

Therefore, serum fetuin-B is related to methionine, which can be used as a biomarker of oxidative stress

Xue S, Han H, Rui S,et al.

Serum Fetuin-B Levels Are Elevated in Women with Metabolic Syndrome and Associated with Increased Oxidative Stress in this message