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    Home > Active Ingredient News > Endocrine System > OMCL: The renal protection induced by aerobic exercise in obese Zucker rats depends on the bioavailability of nitric oxide

    OMCL: The renal protection induced by aerobic exercise in obese Zucker rats depends on the bioavailability of nitric oxide

    • Last Update: 2021-10-20
    • Source: Internet
    • Author: User
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    The gas signaling molecule nitric oxide (NO-) may play an important role in the body, including regulating renal hemodynamics
    .


    With l-arginine as a substrate, NO synthase (NOS) activity increases NO production, and/or reduces NO degradation, and regulates NO bioavailability


    With l-arginine as a substrate, NO synthase (NOS) activity increases NO production, and/or reduces NO degradation, and regulates NO bioavailability.


    Results: Obese+AT rats improved blood glucose homeostasis, systolic blood pressure, aerobic capacity, renal mitochondrial integrity, redox balance, and inflammatory features (such as TNF-α, CRP, IL-10, IL-4 and IL-17a) ) And renal no metabolism related molecules (klotho/FGF23 axis, vasoactive peptide, renal histology and proteinuria reduction)
    .


    However, the above-mentioned positive results were not observed in the CTL-Obese and obesity+AT+L-NAME (p<0:0001) groups


    Table 1 Responses to body weight, blood pressure, metabolic parameters and physical fitness before and after training
    .

    Table 1 Responses to body weight, blood pressure, metabolic parameters and physical fitness before and after training
    .


    Figure swelling and products of kidney mitochondria in response to oxygen
    .


    The data are expressed as mean±standard deviation


    Figure swelling and products of kidney mitochondria in response to oxygen


    Table 2 Kidney morphology, nitric oxide metabolism and inflammation
    .

    Table 2 Kidney morphology, nitric oxide metabolism and inflammation
    .


    Conclusion: In obese Zucker rats, AT is an important non-drug intervention to improve renal function
    .


    However, these renal and metabolic benefits promoted by AT depend on the bioavailability of NO and its underlying regulatory mechanism


    In obese Zucker rats, AT is an important non-drug intervention to improve renal function


    Neves RVP, Corrêa HL, de Sousa Neto IV, et al.


    Renoprotection Induced by Aerobic Training Is Dependent on Nitric Oxide Bioavailability in Obese Zucker Rats in this message
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