On December 27, 2021, Shen Li's laboratory co-published a paper in EMBO Journal to reveal the heterogeneity of adult bone stem progenitor cells

The development, maintenance and remodeling of adult bones are jointly maintained by a variety of region-specific skeletal stem cells ( SSCs )

2021 Nian 12 Yue 27 days, the Institute of Medicine Yue Rui Laboratory Life Science and Technology, Tongji University, East Hospital, Joint regenerating our hospital laboratory sink stand in the EMBO Journal , published online entitled Single-cell transcriptomics of LepR-positive skeletal stress-dependent stem and progenitor pools cells reveals heterogeneous paper

The researchers first combined the mouse genetic lineage tracing system and scRNA-seq to compare the similarities and differences between Prxx1-Cre (the most commonly used limb bone-specific Cre ) and Lepr-Cre labeled cells in

The adipocyte group mainly includes multiple BMSC subgroups that highly express hematopoietic maintenance factors such as Scf and Cxcl12 .

The group of osteoblasts increased significantly after bone fractures and sublethal dose irradiation in mice.

Finally, the researchers also deeply studied the Lepr-Cre+ cell group

Professor Yue Rui of Tongji University and Professor Shen Li of Zhejiang University are the co-corresponding authors of this article, and PhD students Mo Chunyang and Guo Jingxin are the co-first authors of this article

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