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Hepatoid adenocarcinoma of the stomach (HAS) is a very rare but highly malignant gastric tumor in clinical practice
Recently, the team of Professor Ji Jiafu of Gastrointestinal Surgery of Peking University Cancer Hospital and the team of Peking University Biomedical Frontier Innovation Center (BIOPIC) and Professor Bai Fan of the School of Life Sciences jointly published an online publication titled " Genomic and transcriptomic profiling of hepatoid adenocarcinoma " in Oncogene.
Figure 1: Research strategy for gastric liver-like adenocarcinoma
Researchers conducted multi-omics joint analysis on gastric hepatoid adenocarcinoma, and comprehensively applied exon sequencing, transcriptome sequencing and single-cell transcriptome sequencing methods, and completed 58 tumor tissues of 55 patients with gastric hepatoid adenocarcinoma.
Figure 2: Monoclonal origin characteristics of gastric liver-like adenocarcinoma
In order to further explore the gene expression characteristics of gastric liver-like adenocarcinoma, the researchers systematically compared the expression profiles of gastric liver-like adenocarcinoma with gastric adenocarcinoma and hepatocellular carcinoma
Figure 3: Gene expression characteristics of gastric liver-like adenocarcinoma
Finally, using single-cell transcriptome research methods, the researchers conducted a preliminary exploration of the tumor microenvironment of gastric-hepatoid adenocarcinoma and discovered the complex cell differentiation characteristics of gastric-hepatoid adenocarcinoma (Figure 4)
Figure 4: The complex cell differentiation characteristics and tumor microenvironment of gastric liver-like adenocarcinoma
In summary, this study systematically analyzed the molecular characteristics of gastrohepatoid adenocarcinoma at the genome, transcriptome, and microenvironmental levels
Professor Ji Jiafu and Professor Bu Zhaode of Gastrointestinal Surgery of Peking University Cancer Hospital, Peking University Biomedical Frontier Innovation Center (BIOPIC) and Professor Bai Fan from the School of Life Sciences are the co-corresponding authors of the paper
Original link: https://doi.
Reference :
Ishikura H, Fukasawa Y, Ogasawara K, Natori T, Tsukada Y, Aizawa M.
Su JS, Chen YT, Wang RC, Wu CY, Lee SW, Lee TY.
Liu X, Cheng Y, Sheng W, Lu H, Xu X, Xu Y et al .