Oncogene: How Inflammation Causes Gastric Cancer

Now, nearly forty years later, researchers from Kanazawa University and the Japanese Medical Research and Development Institute have finally revealed how inflammation caused by Helicobacter pylori infection can lead to the proliferation of gastric epithelial stem cells, which in turn leads to gastric tumors

In a recent report published in the cancer genetics journal Oncogene, the researchers described how they solved this mystery based on previous discoveries

The lead author of the study, Dr.

NOXO1 is a component of the NOX1 complex, which produces tissue damage molecules called reactive oxygen species (ROS)

In a newly published study, the research team showed that inflammation caused the overproduction of nox1 complex protein by NF-κB signaling

Knowing this, the researchers used a drug to inhibit the activity of the NOX1 complex, which immediately stopped the growth of gastric cancer cells

The senior author of the study, Dr.

Journal Reference :

1. Kanae Echizen, Keigo Horiuchi, Yayoi Aoki, Yoichi Yamada, Toshinari Minamoto, Hiroko Oshima, Masanobu Oshima.