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    Home > Active Ingredient News > Antitumor Therapy > Oncologist: Molecular spectrum and frequency pattern of somatic mutations in Arab women with breast cancer

    Oncologist: Molecular spectrum and frequency pattern of somatic mutations in Arab women with breast cancer

    • Last Update: 2021-08-26
    • Source: Internet
    • Author: User
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    Breast cancer (BC) is still the leading cause of female cancer and the second most common cause of death worldwide
    .


    In recent years, next-generation sequencing (NGS) has played a key role in understanding and identifying altered genetic pathways involved in the development and progression of cancer


    Breast cancer (BC) is still the leading cause of female cancer and the second most common cause of death worldwide


    A total of 78 Arab women with breast cancer were included in this analysis, using NGS containing 46 genes [CMS46] or 50 genes [CMS50] for somatic mutation detection
    .


    The median age at diagnosis was 52.


    A total of 78 Arab women with breast cancer were included in this analysis, using NGS containing 46 genes [CMS46] or 50 genes [CMS50] for somatic mutation detection


    Clinical features

    Clinical features

    There were 18 (23.
    1%) and 60 (76.
    9%) patients tested by NGS CMS46 and CMS50, respectively
    .


    Common somatic mutations are: TP53, 23.


    There were 18 (23.


    Common mutant genes

    Common mutant genes

    In summary, the study clarified the frequency of somatic mutations in Arab women with breast cancer, indicating a certain difference from the Western population
    .


    These data need to be more large-scale epidemiological study to assess such mutations in the prognosis and personalized management role in


    In summary, the study clarified the frequency of somatic mutations in Arab women with breast cancer, indicating a certain difference from the Western population


    Original source:

    H UMAID O.


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