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Triple negative breast cancer (TNBC) is the most aggressive and deadly subtype of breast cancer, with a 5-year survival rate of only about 20%, of which tumor metastasis accounts for more than 90% of TNBC deaths
.
Tumor metastasis is a complex process, and the "seed-soil" theory is a widely recognized mechanism of metastasis, that is, the circulating tumor cells (CTCs) that invade the circulatory system from in situ are compared to "seeds", and CTCs are The metastatic microenvironment at the site is likened to "soil"
Wang Jianxin's research group from the School of Pharmacy, Fudan University published a research result entitled "Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches" in Science Advances on February 11, 2022 , designed a simple and efficient novel multifunctional ginsenoside liposome, which can target and capture CTCs while destroying the metastatic microenvironment of cancer cells, thereby achieving a significant effect of inhibiting lung metastasis of triple-negative breast cancer
.
Ginsenoside liposomes efficiently inhibit TNBC metastasis by trapping CTCs and disrupting the metastatic microenvironment
Ginsenoside Rg3 is a natural active ingredient derived from ginseng.
The team found that it has multiple functions such as drugs, membranes, and targets
A.
The glycosyl group of ginsenoside Rg3 (purple) protrudes from the surface of the liposome bilayer (green) (which can bind to the overexpressed Glut1 on the surface of CTCs); B.
The ginsenoside liposomes target and capture CTCs in blood vessels; C .
Ginsenoside liposomes inhibit the secretion of CCL2 in tumor cells; D.
Ginsenoside liposomes loaded with chemotherapeutic drugs significantly inhibit the lung metastasis of TNBC
.
In this study, ginsenoside liposomes loaded with chemotherapeutic drugs were prepared by replacing cholesterol in liposomes with Rg3, which fully exerted the multiple functions of ginsenosides, and at the same time realized the destruction of tumor metastasis "seeds" and "soil", and played an important role.
The role of "two birds with one stone"
.
The preparation does not require complex chemical modification, has a simple preparation process and controllable cost, and has a strong prospect of clinical transformation
The research group has carried out a lot of research on novel multifunctional liposomes based on ginsenosides for tumor treatment, and has been published in Asian Journal of Pharmaceutical Sciences (2022), Journal of Controlled Release (2021), Nano-Micro Letters (2020) ), Theranostics (2019) and other journals published several related research papers
.
Among them, the ginsenoside Rg3 liposome containing paclitaxel has completed non-clinical research in cooperation with enterprises, and will apply for clinical research approval as a class 1 new drug in October 2021
Xia Jiaxuan, a doctoral student at the School of Pharmacy, Fudan University, is the first author of the paper, and Professor Wang Jianxin is the corresponding author of the paper
Paper link: http://doi.
