One vaccination achieved almost complete protection effect Johnson and Johnson's new crown vaccine animal experiment results are excellent.

For the study, Johnson and Johnson researchers used the Ad26 adenovirus vector to express seven different new coronavirus tingling proteins.
they have made different modifications to the prickly protein, some to make the expression of the hedgehog protein higher levels, while others to enhance the stability of the hedgehog protein, so as to better stimulate the immune response produced by animals.
Johnson and Johnson has developed several virus vaccines using the Ad26 adenovirus technology platform.
month, the Ebola virus vaccine, developed using the same Ad26 adenovirus vector and production model, was approved for release by the European Commission, demonstrating the safety and immunogenicity of the vaccine technology.
researchers vaccinated a total of 52 rhesus monkeys against new crown candidates with different designs.
they found that a candidate vaccine called Ad26.COV2.S (Ad26-S.PP) in the Nature paper was able to stimulate the strongest liposing antibody response.
candidate vaccine expresses a full-length transmean hedgehog protein, introduces mutations at the furin cutting point, and introduces two proline mutations that increase stability.
differences in the structure of the seven different candidate new crown vaccines (Photo source: Reference: Reference 2) Using fake and live neo-coronavirus testing, Ad26.COV2.S-stimulated serum and antibody titrations were four times higher than in previous studies of rehab rhesus monkeys and rehab patients with COVID-19.
, Ad26.COV2.S is able to stimulate prickly protein-specific IgG and IGA antibody reactions in bronchopal bubble irrigation (BAL) samples.
six weeks after vaccination, the researchers tested all the animals.
RNA for the new coronavirus was detected in BAL and nasal swab samples from all control groups.
of the six animals vaccinated against Ad26.COV2.S, no RNA from the new coronavirus was detected in the BAL samples of all animals, and very low levels of the new coronavirus RNA were detected in only one animal in the nasal swab sample.
means that the new crown vaccine provides complete or almost complete protection to the upper and lower respiratory tracts of animals.
candidate new crown vaccine produces almost complete protection for animals (BAL: bronchopulmonal bathing, S.PP is the animal group for the candidate new crown vaccine, Picture: Resources: s1) Single Dose of Johnson and Johnson COVID-19 Vaccine Candidates Robust Protection in Pre-clinical. Retrieved July 30, 2020, from s.2. Mercado et al., (2020). Single-shot Ad26 vaccine protects againST SARS-CoV-2 in rhesus macaques. Nature,