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We already know that almost all living things on Earth have a genetic material DNA (deoxyribonucleic acid), which in turn is made up of four bases: adenine (A), thymus (T), cytosine (C) and ostrich (G), where A is paired with T, C and G respectively.
it is precisely because of these base changes that life is so colorful, and it is precisely because the DNA of each organism has its stability that it ensures the stable continuation of the species.
, however, an earlier team of scientists from the Scripps Institute in California announced that they had successfully added a pair of artificial bases to the lab using the four bases to synthesize a "stable" organism.
the organism has even grown slowly to become a "living organism" with synthetic DNA.
study has been published in the Proceedings of the National Academy of Sciences.
can split normally, and can even be passed on to offspring The team added artificial bases X and Y to E. coli's DNA, eventually succeeding in normally dividing E. coli with synthetic DNA and becoming a "stable semi-synthetic organism."
can say that this is a completely new life that has never existed on Earth.
same team bred similar single-celled organisms as early as 2014.
when they announced that they had created two pairs of artificial bases X and Y, and successfully inserted the new pair into E. coli's DNA to create the first semi-synthetic organism.
artificial base research has been named one of the top ten scientific breakthroughs in 2014 by the American journal Science.
only then did the researchers find that the semi-synthetic organisms they created were growing slowly, and that their unnatural base X and Y could not be transmitted permanently and would quickly disappear during replication as the cells split.
further development of the study, they finally announced that the semi-synthetic organisms that have been bred today have become "stable" by optimizing the artificial base approach.
this "stability" means that optimized semi-synthetic organism cells remain artificial X and Y bases after 60 splits.
researchers believe that their improvements have allowed semi-synthetic organism cells to retain the two artificial bases indefinitely during the division process.
if synthetic organisms are to become real creatures, genetic information must remain stable and stable DNA can be passed on to future generations.
the stability of this "infinite reservation" meets this requirement.
optimization trilogy: accelerating, improving recognition, and making mistakes The research team includes not only Americans, but also scientists from China and France.
Floyd Romesberg, head of research and development, said: "We have made this semi-synthetic organism more like life.
" he described three major improvements in the new study: first, they optimized the nucleotide transport tools used, accelerated E. coli growth, and easily retained base X and Y when splitting; Enzyme recognition makes it easier for cells to replicate artificial base pairs; third, researchers have developed a error-checking tool using CRISPR-Cas9, the latest gene editing tool, that treats gene sequences that do not contain X and Y base pairs as foreign invaders, so that cells without X and Y bases are destroyed.
, they write, is a starting point for the creation of organisms with completely unnatural properties and characteristics.
the results will help scientists continue to develop new proteins to invent new drugs and even help people make major breakthroughs in nanotechnology.
(Jianping) Source: Yangcheng Evening News.