Over 170 million! Seven biomedical "major research plans" 2017 project guidelines were published, and the latest batch of applications began

Source: Bioscience 2017-07-12 since January 22, the website of the National Natural Science Foundation of China has successively published the 2017 project guidelines for 16 major research plans, including 7 related to biomedicine The details are as follows: Note: the regulatory mechanism of vascular homeostasis and remodeling the total direct cost of major research projects to be funded is not directly marked in the guide What is the "major research project" calculated based on the information? It is reported that the NSFC started to pilot the implementation of the major research plan of NSFC in 2001 The plan is aimed at two core basic scientific issues, namely, the national major strategic needs and the major scientific frontier It focuses on deployment in combination with the areas with foundation and advantages in China, gathers the strength of advantages, forms a project group with relatively unified goals or directions, and strengthens the in-depth research and integration of key scientific issues, so as to realize the leaping development of several key areas and important directions Major research projects are divided into three categories: "cultivation project", "key support project" and "integration project" The funding period of "cultivation project" is generally 3 years, the funding period of "key support project" is generally 4 years, and the funding period of "integration project" is determined by each major research plan guidance expert group according to the actual needs As of July 10, 2017, 16 "major research plans" 2017 project guidelines were released on the official website of NSFC The guide defines the scientific objectives, core scientific issues, research direction to be funded in 2017, funding plan in 2017, application requirements and precautions of each "major research plan" The following are the details of the 2017 project guidelines of the five biomedical "major research plans" published this week: the mechanism of organ aging and organ degenerative change major research plan 2017 project guidelines I scientific objectives this major research plan aims to clarify the common mechanism and organ specific changes of tissue and organ aging and degenerative change Focusing on the aging of important human tissues and organs (such as brain, cardiovascular, kidney and blood system) and the early process of their evolution to degenerative change, clarifying the characteristics of molecular, cellular and functional changes related to organ aging and organ degenerative change, elaborating the regulatory mechanism of organ aging and its evolution to degenerative change, strengthening the understanding of the occurrence and development of aging related diseases, opening up To develop a series of new technology research related to aging and organ degeneration, and further establish coping strategies for aging related diseases 2、 Core scientific issues (1) molecular, cellular and functional changes and rules of organ aging and its evolution to degenerative change; (2) role and regulatory mechanism of organ aging to degenerative change in the occurrence and development of diseases in the elderly; (3) early biomarkers and related detection technologies in the process of organ aging and its evolution to degenerative change 3、 2017 key research directions According to the overall layout of this major research plan, in 2017, it is proposed to focus on the following research directions, encourage researchers to adopt interdisciplinary research methods, focus on cooperation with life science, information science, chemistry and other fields, put forward new ideas, new principles, and establish new methods and new technologies for Research on organ aging and organ degenerative change （1） To establish new techniques and methods related to aging and degeneration of tissues and organs Focus on cutting-edge scientific issues of organ aging and degenerative change, encourage interdisciplinary research, and develop new technologies and methods It includes the establishment of new aging research model by using different model organisms, detection technology of aging and degenerative change markers, cell reprogramming technology, targeted gene editing and tracing technology, visual detection technology of epigenetic modification, single cell technology, mass spectrometry detection technology, molecular imaging technology, nano drug technology, etc （2） Genetic, epigenetic and molecular network mechanisms in aging and degenerative changes of important human tissues and organs In view of the different stages of aging (especially the early stage of the evolution from organ aging to degenerative changes), the research on the mechanism of genetic factors, epigenetic factors, environmental factors and other factors was carried out We found and identified new aging related genes, noncoding RNA, protein and other key molecules The effects of nucleic acid modification, histone modification, telomere related protein modification, chromatin stability and noncoding RNA on organ aging and degeneration were studied （3） The homeostasis of internal and external environment in aging and degenerative changes of important human tissues and organs To study the mechanism of cell aging caused by homeostasis, key signal pathway of metabolism, small chemical molecules, lipids, hormones and various immune inflammatory factors Through molecular biology, molecular imaging, electrophysiology and biochemical detection technology, the molecular basis and molecular regulatory mechanism of the role of mitochondria, lysosomes and other subcellular organs in aging and organ degeneration were studied （4） Biomarkers of organ senescence and its evolution to degenerative change, and evaluation index system of organ specific senescence and degeneration To search for molecular markers that can reflect the aging and degeneration of organs at the individual, organ, cell and molecular level, to establish a specific aging and degeneration evaluation index system for individuals, organs and cells, to establish a database and big data calculation and analysis platform to study the biological control network and key nodes in the process of organ aging, so as to identify the aging and degeneration of organs and individuals in the early stage Change early warning provides criteria and evaluation basis 4、 2017 funding plan: the direct cost of 2017 major research plan is 35 million yuan There are 22-30 cultivation projects to be funded, with a funding intensity of 600000-800000 yuan / project and a funding period of 3 years The research period in the application should be filled in "January 1, 2018-december 31, 2020"; there are 6-9 key support projects to be funded, with a funding intensity of 2-2.5 million yuan / project and a funding period of 4 years The research period in the application should be filled in "January 1, 2018-december 2021" 31 " 5、 Application requirements and precautions (due to the high repetition of this part, this part of the following four "major research plans" is omitted For details, please click the official website of NSFC to inquire) (I) application conditions The applicant for this major research plan shall have the following qualifications: 1 Experience in undertaking basic research projects; 2 Senior professional and technical position (title) Postdoctoral researchers in the station, those who are studying for graduate degrees, and those who have no work unit or are not in the supporting unit may not apply as applicants （2） Restrictions One For the personnel with senior professional and technical positions (titles), the total number of the following types of projects applied for (including applicants and main participants) and being undertaken (including principals and main participants) is limited to 3: general projects, key projects, major projects, major research plan projects (excluding integration projects and strategic research projects), joint fund projects, youth science Fund project, regional science fund project, excellent youth science fund project, National Science Fund for Distinguished Youth Project, key international (regional) cooperative research project, inter organization international (regional) cooperative research project with direct cost more than 2 million yuan / Project (only as applicant and as person in charge, not as participant), national major scientific research instrument research Research projects (including special fund projects for basic research of scientific instruments and national major research instruments and equipment development projects), research projects of excellent national key laboratories, and emergency management projects with a funding period of more than one year There are no restrictions on the application of Science Fund for Distinguished Young Scholars and Science Fund for Distinguished Young Scholars Before the application is formally accepted, before the NSFC makes a decision on whether to grant or not, and after the application is granted, it is included in the restrictions 2 Applicants (excluding participants) can only apply for one major research project in the same year The person in charge of the project (excluding integration project and strategic research project) who was funded by the major research plan project in the previous year shall not apply for the major research plan project as the applicant in this year （3） Application notes 1 The submission date of the application is 16:00, August 21-25, 2017 2 This major research plan project application is written online The specific requirements for the applicant are as follows: (1) before filling in the application form, the applicant shall carefully read the relevant contents of the application instructions and restrictions in this project guide and 2017 NSFC project guide, and the application projects that do not meet the project guide and relevant requirements will not be accepted (2) The purpose of this major research plan is to focus on core scientific issues and integrate the strategic direction and advantages of multi-disciplinary research into a project cluster The applicant shall, in accordance with the specific scientific problems to be solved in this major research plan and the research directions to be funded published in the project guidelines, draw up the project name, scientific objectives, research contents, technical routes and corresponding research funds (3) The applicant logs in to the science fund network information system https://isisn.nsfc.gov.cn/ (for applicants without system account number, please apply to the fund management contact person of the supporting unit for account opening), and write the application according to the outline and relevant requirements (4) In the application form, select "major research plan" as the funding category, select "cultivation project" or "key support project" as the sub category description, select "mechanism of organ aging and organ degenerative change" as the annotation description, and select the corresponding application code according to the specific research content of the application Applications for projects with inaccurate or unselected selections will not be accepted There shall be no more than two cooperative research units for cultivation projects and key supporting projects (5) The applicant shall write the application according to the writing outline of the application for major research plan, highlight the limited objectives and key breakthroughs, and make clear the contribution to the realization of the overall objectives of the major research plan and the solution of core scientific problems If the applicant has undertaken other science and technology projects related to this major research plan, the difference and connection between the application project and other related projects shall be discussed in the "research basis and working conditions" section of the body of the application Due to the particularity of the research object of medical science, the applicant is requested to pay attention to strictly abide by the relevant regulations and requirements of relevant medical ethics and patients' informed consent and other issues in the process of project application and implementation, including providing the paper certificate of the ethics committee of the unit or superior competent unit in the application (the electronic application shall be attached with scanning copy) (6) The applicant shall carefully read the contents of the budget preparation instructions in the 2017 NSFC project guide, and strictly follow the measures for the management of funds for NSFC funded projects, the supplementary notice on issues related to the management of funds for NSFC funded projects (CAI Ke Jiao [2016] No 19) and NSFC projects In accordance with the requirements of the instructions for the preparation of the project fund budget table, the project fund budget table of the National Natural Science Foundation of China shall be carefully and truthfully prepared and reported (7) After the applicant completes the application, he / she can submit it online