Over 200,000 people study: The use of antibiotics is refreshing, and the risk of diabetes is rising?

Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated fasting blood glucose levels, impaired glucose tolerance, and elevated levels of glycosylated hemoglobin

Diabetes

The gut microbiota is composed of symbiotic microorganisms, which are easily interfered by drugs

There is a close relationship between obesity and DM

In addition to obesity, the effect of antibiotics on the microbiota that may cause type 2 diabetes has also been studied

The study eventually covered 201459 participants, and Table 1 shows their baseline characteristics

201459

Table 2 describes the relationship between the cumulative days of antibiotic prescriptions and the incidence of DM

Cox proportional hazards model In addition, all models show a higher risk of long-term antibiotic use (≥90 days)

The subgroup analysis results of all covariate stratification in Model 3 are shown in Table 3

The subgroup analysis results of all covariate stratification in Model 3 are shown in Table 3

The correlation between the incidence of diabetes and the number of antibiotics is shown in Table 4

The correlation between the incidence of diabetes and the number of antibiotics is shown in Table 4

Although several mechanisms of the relationship between antibiotics and the incidence of diabetes have been proposed, the exact evidence is still unclear

Although several mechanisms of the relationship between antibiotics and the incidence of diabetes have been proposed, the exact evidence is still unclear

The main results of this study also included washout period analysis and no washout period analysis, both of which showed a significant correlation between antibiotic use and the incidence of diabetes

The main results of this study also included washout period analysis and no washout period analysis, both of which showed a significant correlation between antibiotic use and the incidence of diabetes

In general, this study provides actual evidence, this study provides actual evidence, and this study provides actual evidence that proves the dose-dependent relationship between the incidence of diabetes and the cumulative dose of antibiotics and the number of prescription types
.
This retrospective cohort study is the first in Asia to show an association between antibiotic use and newly diagnosed diabetes in a nationally representative population
.
It proved the dose-dependent relationship between the incidence of diabetes and the cumulative dose of antibiotics and the number of prescriptions
.
This retrospective cohort study is the first in Asia to show an association between antibiotic use and newly diagnosed diabetes in a nationally representative population
.
It proved the dose-dependent relationship between the incidence of diabetes and the cumulative dose of antibiotics and the number of prescriptions
.
This retrospective cohort study is the first in Asia to show an association between antibiotic use and newly diagnosed diabetes in a nationally representative population
.
Although these findings do not necessarily make us need to change current antibiotic prescriptions or clinical practice guidelines, this retrospective cohort study does raise the possibility that antibiotics may increase the risk of diabetes in the future
.
In the future, further human and animal studies are needed to determine the exact causality and mechanism of this phenomenon
.

 

Original source:

Sun Jae Park, et al.
Association between antibiotics use and diabetes incidence in a nationally representative retrospective cohort among Koreans.
Scientifc Reports | (2021) 11:21681 | https://doi.
org/10.
1038/s41598-021-01125-5

Leave a message here