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    Home > Active Ingredient News > Immunology News > Oxid Med Cell Longev: Anti-osteoporosis effect of psoralen components on osteoporosis animal models and its possible mechanism

    Oxid Med Cell Longev: Anti-osteoporosis effect of psoralen components on osteoporosis animal models and its possible mechanism

    • Last Update: 2022-01-07
    • Source: Internet
    • Author: User
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    Osteoporosis (OP) is a systemic bone disease characterized by bone loss and bone microstructure deterioration, leading to increased bone fragility and increased fracture risk
    .


    Many risk factors are related to OP, including drugs such as age, race, smoking, alcoholism, low physical activity, hormone-related factors, glucocorticoids, low calcium and vitamin D levels


    Osteoporosis Vitamin D diagnosis

    So far, calcium and vitamin D supplements are the standard options for OP treatment
    .


    Medications, including bisphosphonates, denosumab, and teripate, are also recommended to reduce the risk of vertebral or hip fractures in OP patients


    Recently, there has been an increasing use of complementary and alternative medicine, including herbal medicines in research and clinical practice: they usually have few side effects and are easy to obtain
    .


    Psoralen (FP) is the dry and mature fruit of Psoralea Corylifolia Linn.


    prevention

    We searched PubMed, China National Knowledge Infrastructure, EMBASE, Wanfang, Science Net, China Biomedical Literature Database, Cochrane Library and Chinese VIP Database, and retrieved articles published from the beginning to June 2021
    .


    The inclusion criteria are animal studies to evaluate the effectiveness and safety of IFP in the treatment of OP, regardless of publication status or language


    Stroke Statistics

    This pre-clinical systematic review provides preliminary evidence that psoralen may pass OPG/RANKL/RANK, PPAR-γ/Axin2/Wnt, FOXO3a/Axin2/Wnt, PI3K/Akt/mTOR, estrogen-like effects and GABA The /GAABRI signaling pathway plays a part of anti-OP effect.


    Literature source: Lin Z, Zheng J, Chen J, Antiosteoporosis Effect and Possible Mechanisms of the Ingredients of Fructus Psoraleae in Animal Models of Osteoporosis: A Preclinical Systematic Review and Meta-Analysis.


    Lin Z, Zheng J, Chen J,Antiosteoporosis Effect and Possible Mechanisms of the Ingredients of Fructus Psoraleae in Animal Models of Osteoporosis: A Preclinical Systematic Review and Meta-Analysis.
    Oxid Med Cell Longev 2021;2021 Leave a message here
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