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    Home > Active Ingredient News > Immunology News > Oxid Med Cell Longev: Anti-osteoporosis effect of psoralen components on osteoporosis animal models and its possible mechanism

    Oxid Med Cell Longev: Anti-osteoporosis effect of psoralen components on osteoporosis animal models and its possible mechanism

    • Last Update: 2022-01-07
    • Source: Internet
    • Author: User
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         Osteoporosis (OP) is a systemic bone disease characterized by bone loss and bone microstructure deterioration, leading to increased bone fragility and increased fracture risk
    .
    Many risk factors are related to OP, including drugs such as age, race, smoking, alcoholism, low physical activity, hormone-related factors, glucocorticoids, low calcium and
    vitamin D levels
    .
    In China, the prevalence of OP before 2008 was 14.
    94%, and it rose to 27.
    96% from 2012 to 2015.
    The prevalence of women was higher than that of men

    .
    According to the
    diagnostic criteria of the National Bone Health Alliance , approximately 16% of men over the age of 50 and 29.
    9% of women suffer from osteoporosis

    .
    With the aging of the global population, OP has become a serious global health problem

    .
    Therefore, the treatment of OP patients is imminent

    .

    Osteoporosis Vitamin D diagnosis

        So far, calcium and vitamin D supplements are the standard options for OP treatment
    .
    Medications, including bisphosphonates, denosumab, and teripate, are also recommended to reduce the risk of vertebral or hip fractures in OP patients

    .
    Estrogen therapy, postmenopausal estrogen plus progesterone therapy or raloxifene are suitable for postmenopausal women

    .
    However, although there are many anti-OP drugs with different pharmacological properties and fixed-dose combination therapies, the target therapeutic effect has not been achieved in a considerable number of OP patients

    .
    Therefore, finding an effective and safe drug for osteoporosis is an important challenge facing the industry

    .

        Recently, there has been an increasing use of complementary and alternative medicine, including herbal medicines in research and clinical practice: they usually have few side effects and are easy to obtain
    .
    Psoralen (FP) is the dry and mature fruit of Psoralea Corylifolia Linn.
    It has a long history and is widely used in Asia, especially in China, Japan and South Korea.
    It is used for its curative effect on OP and fractures.
    Asia has a long history and a wide range of applications

    .
    Studies have shown that FP has the effects of dilating coronary arteries, increasing coronary blood flow, anti-tumor, liver protection, estrogen-like effects and anti-OP effects

    .
    The components of FP (IFP) mainly contain furanocoumarin (mainly psoralen and isopsoralen), coumarin (such as psoralen), and flavonoids (mainly psoralen, psoralen) Adipate, melanocephalin and bavarione) and phenolic terpenoids (such as bacchiol)

    .
    Many IFPs have estrogen-like effects

    .
    Recent reports have shown that phytoestrogens have anti-OP effects similar to natural estrogen, but have fewer estrogen-like side effects [19]

    .
    A number of studies have shown that multiple IFPs may have anti-OP effects in vivo and in vitro

    .
    In ovariectomized rats, Corylifolin can prevent bone loss caused by estrogen deficiency and induce differentiation of primary human osteoblasts

    .
    Psoralen and Bakchiol promote osteoclast differentiation and bone resorption by inhibiting protein kinase B (AKT) and activating protein-1 (AP-1) pathways

    .
    However, due to scattered evidence and unclear mechanism of action, the clinical application of FP and IFP is limited

    .
    Systematic reviews and meta-analysis of animal research are considered to be a valuable tool that can provide important insights into the effectiveness of animal research, improve the accuracy of estimated effects, and support further extension to human clinical trials

    .
    It is speculated that IFP has a certain anti-OP effect on OP animal models

    .
    However, it is difficult to translate these beneficial effects of IFP from basic research into clinical applications

    .
    In addition, the uncertain mechanism of IFP and adverse drug reactions should also be considered, which is also the uncertainty and conflict behind the hypothesis

    .
    The evidence in this study is helpful to find potential drugs for
    preventing OP for healthy people , and provides a basis for OP patients with fewer adverse reactions to the treatment of OP
    .
    At present, FP has not been clinically used to treat OP, and there is a lack of clinical evidence.
    This is the key clinical problem we reviewed and resolved in this study

    .
    This research provides a theoretical basis for the application of FP in OP

    .
    Therefore, we conducted a systematic review and meta-analysis of the preclinical evidence of IFP in OP animal models to summarize important results in terms of efficacy and mechanism

    .

    prevention

        We searched PubMed, China National Knowledge Infrastructure, EMBASE, Wanfang, Science Net, China Biomedical Literature Database, Cochrane Library and Chinese VIP Database, and retrieved articles published from the beginning to June 2021
    .
    The inclusion criteria are animal studies to evaluate the effectiveness and safety of IFP in the treatment of OP, regardless of publication status or language

    .
    Exclusion criteria include (1) other types of research (in vitro studies, case reports, clinical trials, reviews, abstracts, comments, and editorials), (2) combination with other compounds, (3) comparison with other traditional Chinese medicines, (4) Non-osteoporosis or bone loss models, (5) studies with insufficient data, (6) lack of controlled studies, (7) repeated publications

    .
    A meta-analysis and review of the animal data of 10 items of experimental
    stroke (Camarades) were carried out using an improved collaborative method to assess the risk of bias in the included studies
    .
    We calculated the relative risk (RR) and standard mean difference (SMD) of the dichotomy results and the continuous results respectively

    .
    When detecting the presence of heterogeneity or significant
    statistical time of heterogeneity (P <0 0 5 or I2> 5 0%), the random effects model, and then further subgroup analysis and regression estimation to determine Meta heterogeneity Source
    .
    In addition, we use a fixed effects model (P≥0:05 or I2≤50%)

    .
    The main observation indicators are bone mineral density (BMD), serum osteocalcin (S-OCN), bone volume/total volume (Bv/Tv), number of bone trabeculae (Tb.
    N), bone trabecular thickness (Tb.
    Th) , Trabecular bone spacing (Tb.
    Sp), bone maximum load and elastic modulus

    .
    The secondary outcome indicator is the anti-osteoporosis mechanism of IFP

    .
    Stata 12.
    0 software was used for statistical analysis of the data

    .
    In total, 16 studies focused on 379 animals

    .
    The risk bias scores of the included studies ranged from 4 to 7, with an average score of 5.
    25

    .
    This study provides preliminary preclinical evidence that IFP can significantly increase S-OCN, BMD, Bv/Tv and Tb.
    N in OP model animals, while Tb.
    Th and Tb.
    Sp significantly decrease (P<0: 05)

    .
    In addition, IFP can significantly increase the maximum bone load and elastic modulus (P<0:05) of bone biomechanical indicators

    .
    In terms of possible mechanisms for the treatment of OP, IFP may be through osteoprotegerin/nuclear factor receptor activator-κB ligand/nuclear factor receptor activator-κB (OPG/RANKL/RANK), peroxisome proliferator It activates the receptor γ (PPAR-γ)/Axin2/Wnt and produces anti-oxidative stress through the forkhead box O3a (FOXO3a)/Axin2/Wnt, thereby exerting an anti-OP effect

    .

    Stroke Statistics

       This pre-clinical systematic review provides preliminary evidence that psoralen may pass OPG/RANKL/RANK, PPAR-γ/Axin2/Wnt, FOXO3a/Axin2/Wnt, PI3K/Akt/mTOR, estrogen-like effects and GABA The /GAABRI signaling pathway plays a part of anti-OP effect.
    In summary, these findings suggest the possibility of developing IFP as a clinical treatment of OP

    .

       Literature source: Lin Z, Zheng J, Chen J, Antiosteoporosis Effect and Possible Mechanisms of the Ingredients of Fructus Psoraleae in Animal Models of Osteoporosis: A Preclinical Systematic Review and Meta-Analysis.
    Oxid Med Cell Longev 2021;2021

    Lin Z, Zheng J, Chen J,Antiosteoporosis Effect and Possible Mechanisms of the Ingredients of Fructus Psoraleae in Animal Models of Osteoporosis: A Preclinical Systematic Review and Meta-Analysis.
    Oxid Med Cell Longev 2021;2021


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