PacBio Adds New Capabilities for Epigenomic Testing and Simplifies Sequencing

PacBio Inc.

Using PacBio's single-molecule sequencing approach, researchers are able to detect modified bases in native DNA during standard HiFi sequencing, providing insights into the epigenome without additional time and cost

According to PacBio, the update also includes extensive workflow improvements to enhance the customer experience, such as streamlining and accelerating library preparation processes and real-time monitoring of instrument performance

Emily Farrow, Ph.

"We found that the CpG methylation patterns detected in the tomato and maize genomes using HiFi sequencing were highly consistent with standard bisulfite sequencing, while distinguishing other short Transposable elements and other sequences that cannot be obtained by read-length methods

Analysis of epigenomes has historically been difficult, sacrificing read length, accuracy, and completeness, and adding complexity to the pipeline

HiFi sequencing just got easier after streamlining the process

Christian Henry, President and CEO of PacBio, said: "Our latest enhancements to the Sequel II and IIe platforms, including 5-base sequencing and improved workflows, promise to simplify the ability to generate high-quality data and help people gain a deeper understanding of the genome's complexity