Pathogenicity of Staphylococcus aureus

Staphylococcus aureus is a common pathogen of Zui in human suppurative infection, which can cause local suppurative infection, pneumonia, pseudomembranous enteritis, pericarditis, and even septicemia, sepsis and other systemic infections The pathogenicity of Staphylococcus aureus mainly depends on its toxin and invasive enzyme: A hemolytic toxin: exotoxin, divided into four kinds: α, β, γ, δ, which can damage platelets, destroy lysosomes and cause local ischemia and necrosis of the body; B leucocyte killer: it can break bad people's white blood cells and macrophages; C plasma coagulase: when Staphylococcus aureus invades the human body, the enzyme makes the fibrin in the blood or plasma deposit on the surface of the bacteria or coagulate, hindering the phagocytosis of phagocytes D deoxyribonuclease: the deoxyribonuclease produced by Staphylococcus aureus can withstand high temperature, which can be used as a basis for identification of Staphylococcus aureus; E enterotoxin: Staphylococcus aureus can produce several protein enterotoxins that cause acute gastroenteritis, which are divided into five serotypes a, B, C, D, e and F When Staphylococcus aureus contaminates the food with more starch and water, such as milk and dairy products, meat, eggs, etc., under suitable temperature conditions, a considerable amount of enterotoxin can be produced within 8-10 hours Enterotoxin can withstand boiling at 100 ° C for 30 minutes without being destroyed The symptoms of food poisoning caused by enterotoxin are vomiting and diarrhea In addition, Staphylococcus aureus also produces epidermolysin, gelatinase, protease, lipase, peptidase, etc.