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Pediatr Blood Cancer: Radiotherapy combined with VPA and bevacizumab in the treatment of glioma is well tolerated

 Last Update: 2021-04-17
 Source: Internet
 Author: User

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The prognosis of high-grade glioma (HGG) and diffuse intrinsic glioma (DIPG) is still not optimistic.

Child Vascular Diagnosis

From September 2009 to August 2015, 38 children with DIPG and HGG (20 in the DIPG group and 18 in the HGG group) aged 3-21 years were enrolled in the study to receive radiotherapy and VPA at a dose of 15 mg/kg/day.

The results showed that during radiotherapy and VPA, adverse reactions of grade ≥3 that required stopping or modifying the VPA dose included grade 3 thrombocytopenia (1), grade 3 weight gain (1), and grade 3 pancreatitis (1).

thrombus

The median event-free survival (EFS) and overall survival (OS) in the DIPG group were 7.

In summary, the results of this study show that radiotherapy combined with VPA and bevacizumab is well tolerated, but it does not seem to improve EFS or OS in children with DIPG or HGG.

Original source:

Jack Meng-Fen Su, et al.

ncbi.

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