Pediatr Infect Dis J: Effect severity of high-dose vitamin D supplements on the severity of upper respiratory tract infections in healthy children
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Last Update: 2020-06-24
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Source: Internet
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Author: User
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Observational studies support the role of vitamin D in reducing the severity of symptoms of viral upper respiratory tract infections (URTI) in adults and childrenThis study assessed whether high winter doses of vitamin D supplementation (2000 IU/day) reduced the severity of URTI symptoms in preschoolchildren compared to the standard dose (400 IU/day)The secondary objective is to assess the effects of high-dose vitamin D supplementation on outpatient visits, emergency department (ED) visits, and antibiotic prescriptionsa secondary analysis of a multisite randomized clinical trial of 703 healthy 1-5-year-olds aged 1-5 in Toronto, CanadaHigh or standard doses of oral vitamin D were randomly assigned 1 winterFor each person with uremia, parents fill out the symptom check form according to the Canadian Acute Respiratory and Influenza ScaleThe severity of symptoms, the frequency of outpatient visits, the number of ED visits, and the antibiotic prescription of URTI were analyzed with negative two-item regression between the groupsthe results of theshowed that the severity of URTI symptoms was not reduced in the high-dose group compared to the standard dose groupHigh doses of vitamin D did not reduce the frequency of outpatient visits (IRR s 1.16; 95% CI: 0.84-1.60), ED visit frequency (IRR s 1.17; 95% CI:0.57-2.40) or antibiotic prescriptions (IRR s.1.02; 95% CI:0.61-1.72)Serum 25-hydroxyl vitamin D (48.7 ng/mL; 95% CI:46.9-50.5) was higher than the standard dose group (36.8 ng/mL; 95% CI:35.4-38.2; P (0.001)in general, high-dose vitamin D supplements did not reduce the severity of URTI symptoms, outpatient visits, ED visits, or antibiotic prescriptions compared to the standard dose groupThese results do not support vitamin D supplements higher than the recommended dose to reduce symptoms of uremia in children
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