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    Home > Biochemistry News > Biotechnology News > Peking University Nature Publishes Breakthrough Research Achievement: Artificial Intelligence Assists Time-Resolved Cryo-EM to Discover Dynamic Regulation Mechanisms of Major Drug Targets

    Peking University Nature Publishes Breakthrough Research Achievement: Artificial Intelligence Assists Time-Resolved Cryo-EM to Discover Dynamic Regulation Mechanisms of Major Drug Targets

    • Last Update: 2022-05-12
    • Source: Internet
    • Author: User
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    Molecular machines of life achieve their special functions through highly complex non-equilibrium kinetic processes and structural changes, which are then precisely regulated by various complex intermolecular interactions




     

    Mao Youdong Laboratory of Peking University has long been committed to the development of cryo-electron microscopy-based kinetic reconstruction methods and their biomedical applications, focusing on the structure, function, kinetic mechanism and biomedical application of target systems with great clinical application prospects, such as proteasome and inflammasome.


     

     

    Figure 1.


     

     

    The process of scientific research is always full of ups and downs


     

    The study found that the activation of USP14 is dependent on both ubiquitin recognition and the binding of the proteasome RPT1 subunit


     

     

    Figure 2.


    Zhang Shuwen, a postdoctoral fellow in the research group, and Zou Shitao, a 2019 doctoral student, are the co-first authors of the paper, and Mao Youdong is the corresponding author


     

    Nature paper online link:

    https://doi.



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