People with mild neocephaly can produce a strong T-cell response

BEIJING, Aug. 18 (Xinhua
) -- Even if no virus-specific antibody response is detected, patients with neocyto pneumonia may trigger a strong memory T-cell response, researchers report in the latest issue of Cell. The authors say that natural exposure to or infection with the new coronavirus produces a memory T-cell response, or an important immune component to prevent the seriousness of neocyto pneumonia."In the absence of a protective vaccine, it is critical to identify infected people, especially those with asymptomatic or mild illness, who have a strong adaptive immune response to the new coronavirus," said Marcus Bugt of the Karolinska Institute in Sweden, senior author of the
study. So
, there have been very few cases of re-infection in patients who have previously been infected with neo-crown pneumonia. Most studies related to the body's immune protection against neo-coronavirus focus on induction and antibodies, but antibody responses are weakened and cannot be detected in all patients with neocooprosis, especially those with mild illness.
in mice, the vaccine-induced memory T-cell response can last for years and can resist viruses even without detectable antibodies. So far, it is not clear how the neo-coronavirus-specific T-cell response is related to the human antibody response or the clinical process of neo-corona pneumonia in the human body.
for more information, the Bugt team evaluated the response of more than 200 Swedes to new coronavirus-specific T-cells and antibodies throughout the exposure, infection and development of neocyto pneumonia.
results showed that all 23 patients with severe neo-coronary pneumonia recovered and produced neo-coronavirus-specific antibodies and T-cell reactions. Surprisingly, however, in the months after infection, neo-coronavirus-specific memory T-cell reactions were detected in family members who were exposed to the new coronavirus and in most patients with mild neo-coronary pneumonia. In addition, of the 28 family members exposed to the virus, only 17 (more than half) had detectable antibody reactions, while almost all (26/28) showed T-cell responses. Of the 31 patients recovering from neo-coronary pneumonia, 27 detected antibody responses and 30 developed T-cell responses.
, they will determine whether a powerful memory T-cell response can prevent new coronary pneumonia in the long term without detectable antibodies, said Mr. Bugt.