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Scientists say they have discovered a mechanism that explains how fine air pollution particles can lead to lung cancer, according to a study published in eLife
The findings could lead to new ways to prevent or treat the initial lung changes that lead to the disease, the researchers said
“Fine inhalable fine particulate matter (FPM) found in air pollutants has been identified as a Group 1 carcinogen and poses a significant threat to global health
"Here, by studying the biological activity of FPMs in a mouse model of lung cancer, we found that these particles promote lung tumor progression by inducing abnormal thickening of the tissue matrix and hindering the migration of antitumor immune cells
At the same time, inhibition of PXDN activity invalidated the tumor-promoting effect of FPM, indicating the critical impact of aberrant PXDN activity on tumorigenesis
"Taken together, our findings elucidate a novel mechanism by which fpm induces lung tumorigenesis and identify PXDN as a potential target for the treatment or prevention of fpm-related biological risks