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    Home > Biochemistry News > Biotechnology News > Peroxidase - a new target to prevent lung cancer from air pollution?

    Peroxidase - a new target to prevent lung cancer from air pollution?

    • Last Update: 2022-05-19
    • Source: Internet
    • Author: User
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    Scientists say they have discovered a mechanism that explains how fine air pollution particles can lead to lung cancer, according to a study published in eLife


    The findings could lead to new ways to prevent or treat the initial lung changes that lead to the disease, the researchers said


    “Fine inhalable fine particulate matter (FPM) found in air pollutants has been identified as a Group 1 carcinogen and poses a significant threat to global health


    "Here, by studying the biological activity of FPMs in a mouse model of lung cancer, we found that these particles promote lung tumor progression by inducing abnormal thickening of the tissue matrix and hindering the migration of antitumor immune cells


    At the same time, inhibition of PXDN activity invalidated the tumor-promoting effect of FPM, indicating the critical impact of aberrant PXDN activity on tumorigenesis


    "Taken together, our findings elucidate a novel mechanism by which fpm induces lung tumorigenesis and identify PXDN as a potential target for the treatment or prevention of fpm-related biological risks


    Inhaled fine particulate matter (shown in red in the image) pulled on collagen threads, disrupting the immune defenses of mice with lung cancer cells


    To explore this possibility, Wang and his team collected FPM from seven locations in China and studied its effects on the main immune cells that defend against tumor-growing cytotoxic T cells (ctl)


    To investigate why CTLs did not enter the lungs as quickly in FPM-exposed lungs, the team studied CTLs themselves and lung tissue structure


    When the team studied the movement of CTLs in mouse lung tissue exposed to FPM, CTLs had difficulty moving, whereas CTLs in untreated tissue moved freely


    Further analysis of the tissue revealed that the structural changes were caused by an increase in collagen subtypes


    "The most surprising discovery was the mechanism by which this process occurs," Wang said


    "Our study revealed a completely new mechanism that promotes the development of lung tumors through inhalation of fine particulate matter," concluded senior author Dr.


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