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Primary liver cancer is a highly malignant tumor, in which hepatocellular carcinoma (HCC) accounts for about 90% of primary liver cancer
.
Currently, anti-HCC treatments include liver transplantation, hepatectomy, radiotherapy, systemic chemotherapy, interventional therapy, molecular targeted therapy, and immunotherapy
Primary liver cancer Primary liver cancer Hepatocellular carcinoma (HCC) Hepatocellular carcinoma (HCC)
Astragalus is one of the commonly used Chinese medicines for the clinical treatment of HCC .
It is mainly composed of astragalus polysaccharide (APS) and astragaloside IV, which hasthe effect of enhancing immune function
.
APS as a main active ingredient, astragalus, having a broad-spectrum anti-tumor effect, safety, toxicity and other advantages
Astragalus is one of the clinical treatment of HCC commonly used traditional Chinese medicine Astragalus is commonly used in traditional Chinese medicine clinical treatment of HCC, one of Astragalus polysaccharide (APS) Astragalus polysaccharide (APS) to enhance immune function and enhance immune function broad-spectrum anti-tumor effect, safe and low toxic broad-spectrum anti-tumor Function, safety, low toxicity APS combined with a variety of chemotherapeutic drugs APS combined with a variety of chemotherapeutic drugs
The tumor microenvironment affects the occurrence and development of tumors, and the inflammatory microenvironment is an important part of the tumor microenvironment
.
Many traditional Chinese medicines have significant intervention effects on the inflammatory microenvironment of tumors and are important means for the treatment of HCC
Inflammatory microenvironment Inflammatory microenvironment Tumor-associated macrophages (TAMs) Tumor-associated macrophages (TAMs)
A study published recently in Pharm Biol hypothesized that APS participates in the polarization of TAMs in HCC to inhibit HCC-like phenotypes such as cell proliferation, migration, and invasion
.
In this study, TAMs were treated with 0, 8, and 16 mg/mL APS for 24 h
Assume that APS is involved in the polarization of TAMs in HCC.
The results showed that APS 16 mg/mL treatment enhanced the expression of M1 macrophage markers (iNOS, IL-1β and TNF-α) and the proportion of M1 macrophages in TAMs, and reduced the M2 macrophage markers (IL- 10.
The expression of Arg-1) and the ratio of M2 macrophages
.
In addition, APS-mediated TAM-M1 phenotype significantly inhibited the proliferation, migration and invasion of MHCC97H and Huh7 cells
Enhanced M1 macrophage markers in TAMs Enhanced M1 macrophage markers in TAMs Decreased M2 macrophage markers Decreased M2 macrophage markers
In the mouse HCC model, APS suppresses the HCC-like phenotype by inhibiting the M2 polarization of TAMs
.
This research provides a new theoretical basis for the application of astragalus polysaccharides in the clinical treatment of liver cancer
It provides a new theoretical basis for the application of astragalus polysaccharide in the clinical treatment of liver cancer.
Literature source:
Literature source:Li Chun.
Li Chun.
, Pan Xin-You.
, Ma Mingyun.
, Zhao Jun.
, Zhao Fengda.
, Lv Ya-Ping.
(2021).
Astragalus polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of .
tumour-associated macrophages Pharm Biol, 59 (1), 1533-1539 doi:.
10.
1080 / 13880209.
2021.
1991384 in this message
