echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Drugs Articles > Pharmaceutical grade ethyl paraben 1kg specification bacteriostatic application excipient

    Pharmaceutical grade ethyl paraben 1kg specification bacteriostatic application excipient

    • Last Update: 2022-08-20
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Pharmaceutical grade ethyl hydroxybenzoate 1kg specification bacteriostatic application excipient QiangbenyizhiEthyl Hydroxybenzoate C9H10O3 166.
    18 [120-47-8] Ethyl hydroxybenzoate, esterified by ethanol and paraben
    .

    Calculated by dry product, the content of C9H10O3 should be 98.
    0%~102.
    0%
    .

    The appearance of ethyl paraben is white crystalline powder
    .

    Ethylparaben is readily soluble in methanol or ethanol, and almost insoluble in water
    .

    Melting point The melting point of this product (general rule 0612) is 115~118℃
    .

    [Identification] (1) In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution
    .

    (2) Take this product, dissolve it in ethanol and dilute it to make a solution containing about 5μg per 1ml.
    According to the UV-Vis spectrophotometry (General Rule 0401), it has the maximum absorption at the wavelength of 259nm
    .

      (3) The infrared absorption spectrum of this product should be consistent with the control spectrum (spectrum set 850)
    .

    Ethyl paraben, is a white crystalline powder, easily soluble in methanol and ethanol, slightly soluble in glycerol, and almost insoluble in water
    .

    In the presence of non-ionic surfactants, the preservative effect of this product is reduced
    .

    Cross-sensitivity exists between esters of different alkyl groups
    .

    Discoloration in case of iron, easy to hydrolyze in case of strong acid and alkali
    .

    Determination of content: take about 2g of this product, accurately weigh it, put it in a conical flask, accurately add 40ml of sodium hydroxide titration solution (1mol/L), slowly heat to reflux for 1 hour, let it cool to room temperature, add bromothymol 5 drops of blue indicator solution, titrated with sulfuric acid titration solution (0.
    5mol/L)
    .

    Take another 40ml of phosphate buffer (pH6.
    5), add 5 drops of bromothymol blue indicator solution, as the control solution for the end point color; and correct the titration result with a blank test
    .

    Ethyl Hydroxybenzoate, Ethyl Paraben,
    .

    The bacteriostatic effect of ethyl paraben on fungi is strong, but the bacteriostatic effect on bacteria is weak
    .

    As a bacteriostatic preservative, it is widely used in liquid preparations and semi-solid preparations, and can also be used in the preservation of food and cosmetics
    .

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.