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    Home > Biochemistry News > Plant Extracts News > Pharmacodynamics of chlorogenic acid

    Pharmacodynamics of chlorogenic acid

    • Last Update: 2020-04-03
    • Source: Internet
    • Author: User
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    Last revision: 2013-03-12 02:50 classification: efficacy 0 people commented that chlorogenic acid CGA as a free radical scavenger and antioxidant has been proved by a large number of experiments

    This biological activity of CGA can protect the cardiovascular system

    It is known that oxygen free radicals and ox2ldl are one of the important harmful factors that cause endothelial damage, while vascular endothelial cell damage is the basis of pathological state such as platelet aggregation, coagulation, vascular smooth muscle cell apoptosis and proliferation, vascular tension regulation disorder and so on

    Chang Cuiqing et al proved that CGA has a protective effect on the injury of human endothelial cells induced by ox 2ldl

    Chlopcikova et al

    Found that CGA can protect cardiomyocytes from oxidative emergency damage caused by doxorubicin (DOX), and significantly inhibit the iron ion-dependent DOX-induced lipid peroxidation of microsomes and mitochondrial membrane in cardiomyocytes

    The IC50 of CGA was 8.04 ± 0.74 and 6.87 ± 0.52 μ mol / L, respectively

    It can be seen that CGA can protect vascular endothelial cells by scavenging free radicals and anti lipid peroxidation, and then play a role in the prevention and treatment of atherosclerosis, thromboembolism and hypertension

    Animal experiments show that CGA can prevent and inhibit the occurrence of gastric cancer and colon cancer

    The anti mutagenic and anti-cancer mechanism of CGA may be related to the following factors: oxidation promoting effect: Jiang et al

    Found that CGA is a kind of oxidant in alkaline environment, which can cause tumor cells to produce large DNA fragments and nuclear agglutination

    This effect may be related to the oxidation of hydrogen peroxide

    Enhance the activity of arene hydroxylase: arene hydroxylase is an important metabolizing enzyme of polyaromatic hydrocarbon

    The increase of its activity will improve the mutagenic effect of tissue cells against polyaromatic hydrocarbon

    In vitro, CGA has been found to enhance the activity of arene hydroxylase

    Inhibition of 82 hydroxydeoxyguanosine (82oh2dg): 82oh2dg is an important substance in the process of carcinogenesis and cell oxidative stress, which can induce point mutation in mammalian cells

    CGA can inhibit the increase of 82oh2dg induced by 42nitroquinoline 212oxide (4NQO), but has no effect on the level of endogenous 82oh2dg

    The inhibition of carcinogen 2dna adduct [13,15] and the formation of oxygen free radicals is also one of the important mechanisms of its anticancer effect

    CGA can inhibit the growth of Escherichia coli, Shigella sonnei (Group D), Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus and Legionella

    Its antibacterial mechanism is related to the noncompetitive inhibition of arylamine acetyltransferase (NAT) in bacteria

    Hu Kejie et al

    Studied the antiviral effect of CGA in vitro, and found that CGA can significantly inhibit syncytial virus, Coxsackie B group 3, adenovirus 7, etc., and also has a certain inhibitory effect on adenovirus 3 and Coxsackie B5

    Chiang et al also found that CGA had a strong inhibitory effect on adenovirus 11

    Its antiviral mechanism remains to be elucidated

    Intravenous administration of CGA can significantly reduce the content of cholesterol and triglyceride in plasma, and the level of triglyceride in liver

    In addition, CGA and caffeic acid were added to the food of SD rats

    It was also found that vite and cholesterol content in lung, liver and other tissues of SD rats decreased

    In vitro, Chiang et al

    Found that CGA has weak ANTI LEUKEMIA activity

    Bandyopadhyay et al

    Showed that CGA can inhibit bcr2abl and c2abl tyrosine kinase, and induce apoptosis of bcr2abl positive cells including bcr2abl positive primordial lymphocytes in patients with chronic myeloid leukemia

    At the same time, it was found that CGA could destroy the Ph chromosome positive CML cell line K562 implanted in nude mice

    In vitro studies showed that CGA could not only enhance the proliferation of T cells induced by influenza virus antigen, but also induce the production of γ 2ifn and α 2ifn by human lymphocytes and peripheral blood leukocytes

    CGA also increased the levels of IgE, IgG1 and IL24 in rats [29]

    In recent studies, it was also found that CGA can activate neurocalcin to enhance macrophage function

    2.7 the study of antidiabetic effects of andrade2cetto A and wiedenfeld h confirmed that CGA had antidiabetic effects in animals, and there was no statistical difference between CGA and glibenclamide in 3 hours

    The mechanism may be related to the inhibition of glucose 262 phosphotransferase and glucose absorption

    CGA can also inhibit the production of cytokines and chemokines caused by staphylococcal exotoxin, the contraction of fibroblast collagen network caused by hypertrophic scar derived fibroblasts (HTFs) and the increase of ACTH caused by stress response

    Ejzemberg et al

    Found that CGA also has anticomplement effect, and proved that this effect is produced by classical way

    In addition, CGA can affect the concentration of trace elements in plasma

    After intravenous injection of CGA, the content of phosphorus in the plasma of rats decreased significantly, while the content of copper, magnesium, sodium and potassium increased significantly

    This suggests that we should pay attention to the prevention and treatment of electrolyte disorder in clinical application.
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