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    Home > Active Ingredient News > Drugs Articles > Pharmacopoeia standard for pharmaceutical grade sodium bicarbonate 25kg

    Pharmacopoeia standard for pharmaceutical grade sodium bicarbonate 25kg

    • Last Update: 2022-09-07
    • Source: Internet
    • Author: User
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    Pharmaceutical grade sodium bicarbonate 25kg Spot Pharmacopoeia standard NaHCO3 84.
    01 [144-55-8] This product is obtained by passing carbon dioxide into saturated sodium carbonate solution to generate sodium bicarbonate, which is obtained by drying
    .

    Or use sodium chloride, ammonia and carbon dioxide as raw materials, react under certain conditions to generate sodium bicarbonate and ammonium chloride, and obtain them by separation and drying using their solubility differences
    .

    In terms of dry product, the content of NaHCO3 shall not be less than 99.
    0%
    .

    【Properties】This product is white crystalline powder
    .

    This product is soluble in water but insoluble in ethanol
    .

    【Identification】The aqueous solution of this product shows the identification reaction of sodium salt and bicarbonate (General Rule 0301)
    .

    [Check] Take 0.
    20g of this product for alkalinity, add 20ml of water to dissolve it, and measure it according to the law (General Rule 0631).
    The pH value should not be higher than 8.
    6
    .

      For the clarity of the solution, take 1.
    0g of this product, add 20ml of water to dissolve it, and compare the solution with the No.
    2 turbidity standard solution (General Principle 0902 Method 1), and it should not be more concentrated
    .

      For chloride, take 0.
    15g of this product, dissolve it in water and dilute it to 25ml, add nitric acid dropwise to make it slightly acidic, heat it in a water bath to remove carbon dioxide, let it cool, and check according to law (general rule 0801), mix with 3.
    0ml of standard sodium chloride solution Compared with the prepared control solution, it should not be more concentrated (0.
    02%)
    .

      Take 0.
    50g of this product for sulfate, dissolve it in water and dilute it to 40ml, add hydrochloric acid dropwise to make it slightly acidic, heat it in a water bath to remove carbon dioxide, let it cool, and check according to law (general rule 0802), mix it with 1.
    5ml of standard potassium sulfate solution Compared with the prepared control solution, it should not be more concentrated (0.
    03%)
    .

      Take 1.
    0g of this product for ammonium salt, add 10ml of sodium hydroxide test solution, heat it, and the generated steam should not turn blue when it meets the wet red litmus paper
    .

      Take 4.
    0g of this product for loss on drying, put it in a silica gel desiccator for 4 hours, and the weight loss should not exceed 0.
    25% (General Rule 0831)
    .

      Take 1.
    0g of this product as iron salt, dissolve it in an appropriate amount of water, add dilute nitric acid to make it slightly acidic, boil for 1 minute, let it cool, dilute it with water to 25ml, check it according to the law (General Rule 0807), and compare it with 1.
    5ml of standard iron solution.
    Liquid comparison, shall not be deeper (0.
    0015%)
    .

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